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Invitrogen
WAC Polyclonal Antibody
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Product Details
PA5-34536
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide near the center of human WAC
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551888
Product Specific Information
A suggested positive control is human testis tissue lysate.
PA5-34536 can be used with blocking peptide PEP-1579.
Target Information
The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled-coil; WW domain-containing protein 4
Gene Aliases: 1110067P07Rik; A230035H12Rik; AI256735; AI256776; BM-016; DESSH; KIAA1844; PRO1741; RGD1562407; WAC; Wwp4
UniProt ID: (Human) Q9BTA9, (Mouse) Q924H7
Entrez Gene ID: (Human) 51322, (Rat) 307029, (Mouse) 225131
cellular response to DNA damage stimulus
histone monoubiquitination
positive regulation of macroautophagy
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
G1 DNA damage checkpoint
positive regulation of transcription, DNA-templated
histone H2B conserved C-terminal lysine ubiquitination
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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