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Invitrogen
WBSCR22 Polyclonal Antibody
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Product Details
PA5-62566
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WBSCR22. Recombinant protein control fragment (Product #RP-92623).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2649539
Product Specific Information
Immunogen sequence: ELFYDETEAR KYVRNSRMID IQTRMAGRAL ELLYLPENKP CYLLDIGCGT GLSGSYLSDE GHYWVGLDIS PAMLDE
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.
Target Information
The WBSCR22 gene, also known as Williams-Beuren Syndrome Chromosome Region 22, encodes a protein that participates in the biogenesis of the 40S ribosomal subunit. This gene is one of the 26 deleted in Williams-Beuren syndrome, which is characterized by cognitive delays, congenital heart and vascular diseases, and distinct facial features. WBSCR22 features a nuclear localization signal and an S-adenosylmethionine (SAM) binding motif typical of methyltransferases. The protein enhances cell survival and proliferation, with increased expression linked to poor prognosis in various cancers, including glioma and breast cancer. WBSCR22 modulates key signaling pathways such as Akt/GSK3B and beta-catenin/CyclinD1, and is a direct target of miR-146b-5p. Moreover, its downregulation suppresses tumor growth, suggesting its potential as a therapeutic target in oncology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 18S rRNA (guanine-N(7))-methyltransferase; Bud site selection protein 23 homolog; Metastasis-related methyltransferase 1; ribosome biogenesis methyltransferase WBSCR22; rRNA methyltransferase and ribosome maturation factor; Williams Beuren syndrome chromosome region 22; Williams-Beuren candidate region putative methyltransferase; Williams-Beuren syndrome chromosomal region 22 protein
Gene Aliases: BUD23; HASJ4442; HUSSY-03; HUSSY-3; MERM1; PP3381; WBMT; WBSCR22
UniProt ID: (Human) O43709
Entrez Gene ID: (Human) 114049
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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