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Invitrogen
WDR1 Monoclonal Antibody (5C11C8)
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WDR1 Antibody (MA5-49281) in IHC (P)
Immunohistochemistry analysis of WDR1 in paraffin-embedded section of human colorectal adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with WDR1 Monoclonal antibody (Product # MA5-49281) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Conjugated Goat A... View More
Product Details
MA5-49281
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
5C11C8
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human WDR1 (552-579aa MDMMVYVWTLSDPETRVKIQDAHRLHHV).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074939
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Immunogen sequence is different from the related and rat sequences by one amino acid.
Positive Control - WB: human U87 whole cell, human A549 whole cell, mouse lung tissue, mouse liver tissue. IHC: human liver cancer tissue, human colorectal adenocarcinoma tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-interacting protein 1; AIP1; epididymis secretory protein Li 52; NORI-1; WD repeat-containing protein 1; WD40 repeat protein 1
Gene Aliases: AIP1; D5Wsu185e; HEL-S-52; NORI-1; rede; WDR1
UniProt ID: (Human) O75083, (Mouse) O88342
Entrez Gene ID: (Human) 9948, (Mouse) 22388
platelet degranulation
sensory perception of sound
regulation of actin filament depolymerization
positive regulation of actin filament depolymerization
apical junction assembly
maintenance of epithelial cell apical/basal polarity
sarcomere organization
regulation of oligodendrocyte differentiation
regulation of ventricular cardiac muscle cell membrane repolarization
actin cytoskeleton organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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