Proteintech

WDR19/IFT144 Polyclonal Antibody

WDR19/IFT144 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

WDR19/IFT144 Antibody (13647-1-AP) in ICC/IF

IF result (ocalization near the Fleming body) of anti-WDR19 (13647-1-AP, 1:50) with telophase hTERT-RPE1 cells (MeOH fixed) by Dr. Moshe Kim.

WDR19/IFT144 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

WDR19/IFT144 Antibody in Western Blot (WB)

WDR19/IFT144 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13647-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

WDR19/IFT144 Fusion Protein Ag4599 (1-353 aa encoded by BC032578)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKRIFSLLE KTWLGAPIQF AWQKTSGNYL AVTGADYIVK IFDRHGQKRS EINLPGNCVA MDWDKDGDVL AVIAEKSSCI YLWDANTNKT SQLDNGMRDQ MSFLLWSKVG SFLAVGTVKG NLLIYNHQTS RKIPVLGKHT KRITCGCWNA ENLLALGGED KMITVSNQEG DTIRQTQVRS EPSNMQFFLM KMDDRTSAAE SMISVVLGKK TLFFLNLNEP DNPADLEFQQ DFGNIVCYNW YGDGRIMIGF SCGHFVVIST HTGELGQEIF QARNHKDNLT SIAVSQTLNK VATCGDNCIK IQDLVDLKDM YVILNLDEEN KGLGTLSWTD DGQLLALSTQ RGSLHVFLTK LPIL (1-353 aa encoded by BC032578)

Target Information

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

Cell reports

Schembs L,Willems A,Hasenpusch-Theil K,Cooper JD,Whiting K,Burr K,Bøstrand SMK,Selvaraj BT,Chandran S,Theil T

Tue May 17 00:00:00 UTC 2022

Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.

Molecular biology of the cell

Dewees SI,Vargová R,Hardin KR,Turn RE,Devi S,Linnert J,Wolfrum U,Caspary T,Eliáš M,Kahn RA

Fri Apr 01 00:00:00 UTC 2022

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.

eLife

Quidwai T,Wang J,Hall EA,Petriman NA,Leng W,Kiesel P,Wells JN,Murphy LC,Keighren MA,Marsh JA,Lorentzen E,Pigino G,Mill P

Thu Nov 04 00:00:00 UTC 2021

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.

eLife

Quidwai T,Wang J,Hall EA,Petriman NA,Leng W,Kiesel P,Wells JN,Murphy LC,Keighren MA,Marsh JA,Lorentzen E,Pigino G,Mill P

Thu Nov 04 00:00:00 UTC 2021

A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia.

Journal of assisted reproduction and genetics

Ni X,Wang J,Lv M,Liu C,Zhong Y,Tian S,Wu H,Cheng H,Gao Y,Tan Q,Chen B,Li Q,Song B,Wei Z,Zhou P,He X,Zhang F,Cao Y

Mon Jun 01 00:00:00 UTC 2020

Ttc39c is upregulated during skeletal muscle atrophy and modulates ERK1/2 MAP kinase and hedgehog signaling.

Journal of cellular physiology

Hayes CS,Labuzan SA,Menke JA,Haddock AN,Waddell DS

Sun Dec 01 00:00:00 UTC 2019

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

American journal of human genetics

Forbes TA,Howden SE,Lawlor K,Phipson B,Maksimovic J,Hale L,Wilson S,Quinlan C,Ho G,Holman K,Bennetts B,Crawford J,Trnka P,Oshlack A,Patel C,Mallett A,Simons C,Little MH

Thu May 03 00:00:00 UTC 2018

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

American journal of human genetics

Forbes TA,Howden SE,Lawlor K,Phipson B,Maksimovic J,Hale L,Wilson S,Quinlan C,Ho G,Holman K,Bennetts B,Crawford J,Trnka P,Oshlack A,Patel C,Mallett A,Simons C,Little MH

Thu May 03 00:00:00 UTC 2018

iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Liu X,Wang J,Gao L,Liu H,Liu C

Tue Mar 06 00:00:00 UTC 2018

iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Liu X,Wang J,Gao L,Liu H,Liu C

Tue Mar 06 00:00:00 UTC 2018

Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.

PloS one

Xu Y,Cao J,Huang S,Feng D,Zhang W,Zhu X,Yan X

Mon Apr 18 00:00:00 UTC 2016

Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.

PloS one

Xu Y,Cao J,Huang S,Feng D,Zhang W,Zhu X,Yan X

Mon Apr 18 00:00:00 UTC 2016

Primary cilia signaling mediates intraocular pressure sensation.

Proceedings of the National Academy of Sciences of the United States of America

Luo N,Conwell MD,Chen X,Kettenhofen CI,Westlake CJ,Cantor LB,Wells CD,Weinreb RN,Corson TW,Spandau DF,Joos KM,Iomini C,Obukhov AG,Sun Y

Tue Sep 02 00:00:00 UTC 2014

Primary cilia signaling mediates intraocular pressure sensation.

Proceedings of the National Academy of Sciences of the United States of America

Luo N,Conwell MD,Chen X,Kettenhofen CI,Westlake CJ,Cantor LB,Wells CD,Weinreb RN,Corson TW,Spandau DF,Joos KM,Iomini C,Obukhov AG,Sun Y

Tue Sep 02 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Intraflagellar transport 144 homolog; WD repeat membrane protein PWDMP; WD repeat-containing protein 19

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Gene Aliases: ATD5; C330027H04Rik; CED4; D330023L08Rik; DYF-2; DYF2; IFT144; KIAA1638; mKIAA1638; NPHP13; ORF26; Oseg6; PWDMP; RGD1306997; SRTD5; WDR19

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UniProt ID: (Human) Q8NEZ3, (Mouse) Q3UGF1

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Entrez Gene ID: (Human) 57728, (Rat) 305349, (Mouse) 213081

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Function(s)

molecular_function

Process(es)

cell morphogenesis in utero embryonic development smoothened signaling pathway gonad development embryonic limb morphogenesis embryonic camera-type eye development intraciliary retrograde transport cilium assembly ear morphogenesis embryonic cranial skeleton morphogenesis neurological system process digestive system development cilium morphogenesis ciliary receptor clustering involved in smoothened signaling pathway smoothened signaling pathway involved in dorsal/ventral neural tube patterning myotome development cell projection organization protein localization to cilium

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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WDR19/IFT144 Polyclonal Antibody

WDR19/IFT144 Antibody (13647-1-AP) in ICC/IF

Product Details

13647-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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