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Invitrogen
WDR48 Polyclonal Antibody
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WDR48 Antibody (PA5-76203) in IHC (P)
Immunohistochemistry analysis of WDR48 in paraffin-embedded rat liver. Samples were incubated with WDR48 polyclonal antibody (Product # PA5-76203) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-76203
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human WDR48.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719930
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids, which commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms involving signal transduction, apoptosis, transcriptional regulation and cell cycle control. WD repeats serve as sites for protein-protein interaction and some seem to mediate the assembly of protein complexes. With eight WD repeats, WDR48 (WD repeat-containing protein 48), also known as USP1-associated factor 1 and p80, is a 677 amino acid protein that functions to regulate deubiquitinating complexes via activation of USP1, USP12 and USP46. WDR48 enhances deubiquitination by increasing catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. WDR48 is ubiquitously expressed and is mainly localized to the cytoplasm. There are five isoforms of WDR48 that are expressed as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p80; testicular tissue protein Li 224; USP1 associated factor 1; USP1-associated factor 1; WD repeat endosomal protein; WD repeat-containing protein 48
Gene Aliases: 8430408H12Rik; KIAA1449; mKIAA1449; P80; RGD1309702; SPG60; UAF1; WDR48
UniProt ID: (Human) Q8TAF3, (Mouse) Q8BH57
Entrez Gene ID: (Human) 57599, (Rat) 363164, (Mouse) 67561
double-strand break repair via homologous recombination
cellular response to DNA damage stimulus
spermatogenesis
single fertilization
male gonad development
protein deubiquitination
multicellular organism growth
skin development
embryonic organ development
skeletal system morphogenesis
homeostasis of number of cells
positive regulation of epithelial cell proliferation
seminiferous tubule development
regulation of protein monoubiquitination
viral process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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