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Invitrogen
WDR5 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-C223)
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FIGURE: 1 / 3
WDR5 Chimeric Antibody (MA5-48332) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of WDR5 in HeLa cells using WDR5 Chimeric Monoclonal Antibody (Product # MA5-48332). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton and stained with WDR5 Chimeric Monoclonal Antibody at a dilution of 1:100 for 1h followed by Alexa Fluor 488 secondary antibody (1:1,500 dilution), showing nuclear and cytoplasmic staining. Actin filaments... View More
Product Details
MA5-48332
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RAB-C223
Immunogen
This antibody was obtained by recombinant antibody (rAb) phage display recognizing WDR5 protein under non-denaturing conditions.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074774
Product Specific Information
Specificity: This antibody recognizes WDR5 (WD repeat-containing protein 5). It binds to a folded domain, amino acids 1-334. WDR5 is a protein that is involved in histone modification.
Target Information
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3, Set1c WD40 repeat protein, homolog; WD repeat-containing protein 5
Gene Aliases: BIG-3; BIG3; CFAP89; SWD3; WDR5
UniProt ID: (Human) P61964
Entrez Gene ID: (Human) 11091
skeletal system development
transcription, DNA-templated
neuron projection development
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
histone H3 acetylation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
histone H3-K4 methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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