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Product Details
WEE2-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 60-110 on mouse Wee1-like protein kinase isoform 2.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mWee1B; WEE1 homolog 2 (S. pombe); Wee1-like protein kinase 1B; Wee1-like protein kinase 2; Wee1B kinase
Gene Aliases: Gm1065; Wee1B; Wee2
UniProt ID: (Mouse) Q66JT0
Entrez Gene ID: (Mouse) 381759, (Rat) 502750
nucleotide binding
magnesium ion binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
protein serine/threonine kinase activity
protein phosphorylation
mitotic nuclear division
female meiotic division
phosphorylation
peptidyl-tyrosine phosphorylation
female pronucleus assembly
negative regulation of cyclin-dependent protein serine/threonine kinase activity
meiotic cell cycle
regulation of meiosis I
negative regulation of oocyte maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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