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Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymal protein 4; Epididymal secretory protein E4; epididymis-specific, whey-acidic protein type, four-disulfide core; Major epididymis-specific protein E4; MGC57529; Putative protease inhibitor WAP5; WAP domain containing protein HE4-V4; WAP domain-containing protein HE4; WAP four-disulfide core domain protein 2
Gene Aliases: 1600023A02Rik; dJ461P17.6; EDDM4; HE4; WAP5; WFDC2
UniProt ID: (Human) Q14508, (Mouse) Q9DAU7
Entrez Gene ID: (Human) 10406, (Mouse) 67701
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