Proteintech

WFS1 Polyclonal Antibody

View all (9) WFS1 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (2)

WFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

WFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

WFS1 Antibody (26995-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26995-1-AP (WFS1 antibody) at dilution of 1:400 (under 4x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

WFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

WFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

WFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26995-1-AP (WFS1 antibody) at dilution of 1:400 (under 4x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

WFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using 26995-1-AP (WFS1 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Product Details

26995-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

-

View 5 publications 5 publications

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400

-

Immunocytochemistry (ICC/IF)

-

View 6 publications 6 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

WFS1 Fusion Protein Ag25724

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

467 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)

Ma L,Yang S,Yang Y,Chen X,Yang J,He Y,Cheng Q,Li J,Kang B,Tang S,Zhang A,Shu X,Li X,Shen H,Jing Y,Song Y,Li Q,Hu J

Mon May 01 00:00:00 UTC 2023

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)

Ma L,Yang S,Yang Y,Chen X,Yang J,He Y,Cheng Q,Li J,Kang B,Tang S,Zhang A,Shu X,Li X,Shen H,Jing Y,Song Y,Li Q,Hu J

Mon May 01 00:00:00 UTC 2023

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)

Ma L,Yang S,Yang Y,Chen X,Yang J,He Y,Cheng Q,Li J,Kang B,Tang S,Zhang A,Shu X,Li X,Shen H,Jing Y,Song Y,Li Q,Hu J

Mon May 01 00:00:00 UTC 2023

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)

Ma L,Yang S,Yang Y,Chen X,Yang J,He Y,Cheng Q,Li J,Kang B,Tang S,Zhang A,Shu X,Li X,Shen H,Jing Y,Song Y,Li Q,Hu J

Mon May 01 00:00:00 UTC 2023

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)

Ma L,Yang S,Yang Y,Chen X,Yang J,He Y,Cheng Q,Li J,Kang B,Tang S,Zhang A,Shu X,Li X,Shen H,Jing Y,Song Y,Li Q,Hu J

Mon May 01 00:00:00 UTC 2023

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)

Ma L,Yang S,Yang Y,Chen X,Yang J,He Y,Cheng Q,Li J,Kang B,Tang S,Zhang A,Shu X,Li X,Shen H,Jing Y,Song Y,Li Q,Hu J

Mon May 01 00:00:00 UTC 2023

The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory.

Progress in neurobiology

Park SB,Lim HY,Lee EY,Yoo SW,Jung HS,Lee E,Sun W,Lee I

Tue Mar 01 00:00:00 UTC 2022

Wolframin is a novel regulator of tau pathology and neurodegeneration.

Acta neuropathologica

Chen S,Acosta D,Li L,Liang J,Chang Y,Wang C,Fitzgerald J,Morrison C,Goulbourne CN,Nakano Y,Villegas NCH,Venkataraman L,Brown C,Serrano GE,Bell E,Wemlinger T,Wu M,Kokiko-Cochran ON,Popovich P,Flowers XE,Honig LS,Vonsattel JP,Scharre DW,Beach TG,Ma Q,Kuret J,Kõks S,Urano F,Duff KE,Fu H

Sun May 01 00:00:00 UTC 2022

Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer's circuit dysfunction.

eLife

Zhao R,Grunke SD,Wood CA,Perez GA,Comstock M,Li MH,Singh AK,Park KW,Jankowsky JL

Mon Dec 05 00:00:00 UTC 2022

WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome.

Journal of medical genetics

Hu K,Zatyka M,Astuti D,Beer N,Dias RP,Kulkarni A,Ainsworth J,Wright B,Majander A,Yu-Wai-Man P,Williams D,Barrett T

Sat Jan 01 00:00:00 UTC 2022

Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway.

Acta neuropathologica communications

Wang Z,Wang X,Shi L,Cai Y,Hu B

Sat Dec 17 00:00:00 UTC 2022

Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.

Frontiers in endocrinology

Morikawa S,Blacher L,Onwumere C,Urano F

Tue Apr 12 00:00:00 UTC 2022

Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.

Frontiers in endocrinology

Morikawa S,Blacher L,Onwumere C,Urano F

Tue Apr 12 00:00:00 UTC 2022

Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.

Frontiers in endocrinology

Morikawa S,Blacher L,Onwumere C,Urano F

Tue Apr 12 00:00:00 UTC 2022

Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.

Frontiers in endocrinology

Morikawa S,Blacher L,Onwumere C,Urano F

Tue Apr 12 00:00:00 UTC 2022

Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.

Science translational medicine

Delpech JC,Pathak D,Varghese M,Kalavai SV,Hays EC,Hof PR,Johnson WE,Ikezu S,Medalla M,Luebke JI,Ikezu T

Wed Sep 15 00:00:00 UTC 2021

WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells.

Nature communications

Wang L,Liu H,Zhang X,Song E,Wang Y,Xu T,Li Z

Tue Nov 30 00:00:00 UTC 2021

WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells.

Nature communications

Wang L,Liu H,Zhang X,Song E,Wang Y,Xu T,Li Z

Tue Nov 30 00:00:00 UTC 2021

WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells.

Nature communications

Wang L,Liu H,Zhang X,Song E,Wang Y,Xu T,Li Z

Tue Nov 30 00:00:00 UTC 2021

WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells.

Nature communications

Wang L,Liu H,Zhang X,Song E,Wang Y,Xu T,Li Z

Tue Nov 30 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 protein homolog; Wolframin

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Gene Aliases: AI481085; CTRCT41; WFRS; WFS; WFS1; WFSL; wolframin

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UniProt ID: (Human) O76024, (Mouse) P56695

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Entrez Gene ID: (Human) 7466, (Mouse) 22393, (Rat) 83725

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protein binding ubiquitin protein ligase binding activating transcription factor binding ATPase binding calmodulin binding calcium-dependent protein binding transporter activity

negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis visual perception sensory perception of sound ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response positive regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress glucose homeostasis negative regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process positive regulation of growth protein stabilization neurological system process positive regulation of protein metabolic process regulation of cell cycle positive regulation of calcium ion transport calcium ion homeostasis negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of ATF6-mediated unfolded protein response negative regulation of type B pancreatic cell apoptotic process pancreas development olfactory behavior positive regulation of proteolysis polyubiquitinated misfolded protein transport ER overload response protein maturation by protein folding IRE1-mediated unfolded protein response positive regulation of adenylate cyclase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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