Invitrogen

WFS1 Polyclonal Antibody

View all (9) WFS1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-102465

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human WFS1(Accession O76024), corresponding to amino acid residues K193-A243.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851867

Product Specific Information

Antibody detects endogenous levels of total WFS1.

Target Information

WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 protein homolog; Wolframin

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Gene Aliases: AI481085; CTRCT41; WFRS; WFS; WFS1; WFSL; wolframin

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UniProt ID: (Human) O76024, (Mouse) P56695

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Entrez Gene ID: (Human) 7466, (Mouse) 22393, (Rat) 83725

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Function(s)
protein binding ubiquitin protein ligase binding activating transcription factor binding ATPase binding calmodulin binding calcium-dependent protein binding transporter activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis visual perception sensory perception of sound ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response positive regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress glucose homeostasis negative regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process positive regulation of growth protein stabilization neurological system process positive regulation of protein metabolic process regulation of cell cycle positive regulation of calcium ion transport calcium ion homeostasis negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of ATF6-mediated unfolded protein response negative regulation of type B pancreatic cell apoptotic process pancreas development olfactory behavior positive regulation of proteolysis polyubiquitinated misfolded protein transport ER overload response protein maturation by protein folding IRE1-mediated unfolded protein response positive regulation of adenylate cyclase activity
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