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Invitrogen
WFS1 Polyclonal Antibody
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Product Details
PA5-116717
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human WFS1 (NP_0059962)
Conjugate
Form
Liquid
Concentration
1.37 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901348
Product Specific Information
Positive Samples: MCF7, HeLa, Mouse heart, Mouse brain
Immunogen sequence: MDSNTAPLGP SCPQPPPAPQ PQARSRLNAT ASLEQERSER PRAPGPQAGP GPGVRDAAAP AEPQAQHTRS RERADGTGPT KGDMEIPFEE VLERAKAGDP KAQTEVGKHY LQLAGDTDEE LNSCTAVDWL VLAAKQGRRE AVKLLRRCLA DRRGITSENE REVRQLSSET DLERAVRKAA LVMYWKLNPK KKKQVAVAEL LENVGQVNEH DGGAQPGPVP KSLQKQRRML ERLVSSESKN YIALDDFVEI TKKYAKGVIP SSLFLQDDED DDELAGKSPE DLPLR
Target Information
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 protein homolog; Wolframin
Gene Aliases: AI481085; CTRCT41; WFRS; WFS; WFS1; WFSL; wolframin
UniProt ID: (Human) O76024, (Mouse) P56695
Entrez Gene ID: (Human) 7466, (Mouse) 22393, (Rat) 83725
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
visual perception
sensory perception of sound
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
positive regulation of protein ubiquitination
endoplasmic reticulum calcium ion homeostasis
response to endoplasmic reticulum stress
glucose homeostasis
negative regulation of programmed cell death
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron apoptotic process
positive regulation of growth
protein stabilization
neurological system process
positive regulation of protein metabolic process
regulation of cell cycle
positive regulation of calcium ion transport
calcium ion homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of ATF6-mediated unfolded protein response
negative regulation of type B pancreatic cell apoptotic process
pancreas development
olfactory behavior
positive regulation of proteolysis
polyubiquitinated misfolded protein transport
ER overload response
protein maturation by protein folding
IRE1-mediated unfolded protein response
positive regulation of adenylate cyclase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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