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Product Details
H00065268-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2A2
Immunogen
WNK2 (NP_006639, 2118 a.a. approximately 2217 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KGTFTDDLHK LVDEWTSKTV GAAQLKPTLN QLKQTQKLQD MEAQAGWAAP GEARAMTAPR AGVGMPRLPP APGPLSTTVI PGAAPTLSVP TPDPESEKPD
Target Information
WNK2 is a serine/threonine kinase involved in signal transduction and cellular communication. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95% homologous to WNK1. The human WNK1 gene encodes a 2,382 amino acid protein that is primarily expressed in heart, kidney, muscle and distal nephron. The human WNK3 gene encodes a protein that is primarily expressed in brain; the human WNK4 gene encodes a 1,243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption and impaired K+ and H+ excretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antigen NY-CO-43; mitogen-activated protein kinase kinase kinase; Protein kinase lysine-deficient 2; Protein kinase with no lysine 2; protein kinase, lysine deficient 2; Serine/threonine-protein kinase WNK2; Serologically defined colon cancer antigen 43
Gene Aliases: KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43; WNK2
UniProt ID: (Human) Q9Y3S1
Entrez Gene ID: (Human) 65268
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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