Invitrogen

WNT7A Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-28289

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human WNT7A. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2545765

Product Specific Information

Recommended positive controls: WNT7A-transfected 293T.

Predicted reactivity: Mouse (100%), Rat (100%), Chicken (96%), Rhesus Monkey (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of ß-catenin degradation. Intracellular accumulation of ß-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/ß-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: postaxial hemimelia; Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family, member 7A

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Gene Aliases: AI849442; px; tw; Wnt-7a; WNT7A

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UniProt ID: (Human) O00755, (Mouse) P24383

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Entrez Gene ID: (Human) 7476, (Mouse) 22421

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Function(s)
receptor binding frizzled binding cytokine activity protein binding receptor agonist activity
Process(es)
embryonic axis specification cartilage condensation angiogenesis chondrocyte differentiation neurotransmitter secretion axonogenesis synapse assembly sex differentiation asymmetric protein localization dorsal/ventral pattern formation positive regulation of endothelial cell migration skeletal muscle satellite cell activation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Wnt signaling pathway cerebellar granule cell differentiation cell proliferation in forebrain central nervous system vasculogenesis establishment of cell polarity regulation of axon diameter response to estradiol somatic stem cell population maintenance embryonic forelimb morphogenesis embryonic hindlimb morphogenesis non-canonical Wnt signaling pathway Wnt signaling pathway involved in wound healing, spreading of epidermal cells synaptic vesicle recycling embryonic digit morphogenesis negative regulation of apoptotic process response to estrogen cell fate commitment positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade somatic stem cell division stem cell development negative regulation of neurogenesis positive regulation of synapse assembly palate development positive regulation of epithelial cell proliferation involved in wound healing oviduct development canonical Wnt signaling pathway dendritic spine morphogenesis uterus morphogenesis lens fiber cell development cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway positive regulation of protein localization to synapse excitatory synapse assembly positive regulation of excitatory synapse assembly positive regulation of excitatory postsynaptic potential signal transduction cell-cell signaling multicellular organism development positive regulation of cell proliferation organ morphogenesis positive regulation of gene expression embryonic limb morphogenesis forelimb morphogenesis hindlimb morphogenesis regulation of cell proliferation skin morphogenesis reproductive structure development skeletal system morphogenesis regulation of axonogenesis synapse organization cartilage development uterus development limb development positive regulation of receptor activity
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