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OriGene
WWTR1 Monoclonal Antibody (OTI1A12), TrueMAB™
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Product Details
TA503438
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI1A12
Immunogen
Full length human recombinant protein of human WWTR1 produced in HEK293 cell.
Conjugate
Form
Liquid
Concentration
0.61 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain-containing transcription regulator protein 1
Gene Aliases: 2310058J06Rik; 2610021I22Rik; C78399; TAZ; WWTR1
UniProt ID: (Dog) A0A8I3PQN6, (Human) Q9GZV5, (Mouse) Q9EPK5
Entrez Gene ID: (Dog) 609743, (Human) 25937, (Mouse) 97064
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
negative regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of protein kinase activity
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
protein ubiquitination
stem cell division
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
glomerulus development
multicellular organism growth
hippo signaling
negative regulation of catenin import into nucleus
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mesenchymal cell differentiation
cilium morphogenesis
regulation of SMAD protein import into nucleus
regulation of canonical Wnt signaling pathway
kidney morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
negative regulation of canonical Wnt signaling pathway
regulation of nucleic acid-templated transcription
transcription initiation from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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