Invitrogen

XCL1/XCL2 Polyclonal Antibody

View all (2) XCL1/XCL2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-75840

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues in Human XCL1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2719568

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

Lymphotactin, otherwise known as XCL1, is a member of the C-chemokine family that uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation. Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATAC; C motif chemokine 1; C motif chemokine 2; chemokine (C motif) ligand 1; chemokine (C motif) ligand 2; Cytokine SCM-1; Cytokine SCM-1 beta; Lymphotactin; Lymphotaxin; SCM-1-alpha; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small inducible cytokine subfamily C, member 2; Small-inducible cytokine C1; XC chemokine ligand 1; XC chemokine ligand 2

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Gene Aliases: AI661682; ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM-1b; SCM1; SCM1A; SCM1B; SCYC1; SCYC2; XCL1; XCL2

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UniProt ID: (Human) P47992, (Human) Q9UBD3, (Rat) P51672, (Mouse) P47993

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Entrez Gene ID: (Human) 6375, (Human) 6846, (Rat) 171371, (Mouse) 16963

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Function(s)
chemokine activity chemokine receptor binding protein homodimerization activity CCR chemokine receptor binding protein binding cytokine activity
Process(es)
monocyte chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway blood circulation neutrophil chemotaxis positive regulation of GTPase activity lymphocyte chemotaxis positive regulation of inflammatory response chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of T cell mediated cytotoxicity positive regulation of leukocyte chemotaxis negative regulation of T cell cytokine production positive regulation of T cell cytokine production chemotaxis immune response cell-cell signaling response to virus positive regulation of T cell chemotaxis negative regulation of interferon-gamma production negative regulation of interleukin-2 production positive regulation of interleukin-10 production mature natural killer cell chemotaxis negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated regulation of inflammatory response release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol cell chemotaxis cellular response to interleukin-4 cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta production positive regulation of granzyme B production positive regulation of neutrophil chemotaxis positive regulation of thymocyte migration positive regulation of natural killer cell chemotaxis positive regulation of granzyme A production negative regulation of T-helper 1 cell activation positive regulation of B cell chemotaxis positive regulation of T-helper 2 cell cytokine production positive regulation of T-helper 1 cell cytokine production positive regulation of immunoglobulin production in mucosal tissue negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell proliferation negative regulation of T-helper 1 type immune response positive regulation of immune response to tumor cell positive regulation of innate immune response
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