Proteintech

XDH Polyclonal Antibody

XDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

XDH Antibody (55156-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart using 55156-1-AP (XDH antibody) at dilution of 1:100 (under 40x lens).

Product Image Gallery

Product Details

55156-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to XDH.

Target Information

XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Xanthine oxidase, a therapeutic target of realgar for non-small cell lung cancer.

Heliyon

Guo R,Gong X,Li K,Qiu Z,Yang L,Wan Y,Yao X,Long C,Xu J,Li K,Liu J,Liu J

Sun Jan 01 00:00:00 UTC 2023

Milk fat globule membrane proteins are involved in controlling the size of milk fat globules during conjugated linoleic acid-induced milk fat depression.

Journal of dairy science

Huang QX,Yang J,Hu M,Lu W,Zhong K,Wang Y,Yang G,Loor JJ,Han L

Tue Nov 01 00:00:00 UTC 2022

Berberine Attenuates Hyperuricemia by Regulating Urate Transporters and Gut Microbiota.

The American journal of Chinese medicine

Shan B,Wu M,Chen T,Tang W,Li P,Chen J

Fri Nov 25 00:00:00 UTC 2022

Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota.

Food & function

Zhang L,Liu J,Jin T,Qin N,Ren X,Xia X

Mon Nov 28 00:00:00 UTC 2022

Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Bioengineered

Zhao X,Wang J,Tang L,Li P,Ru J,Bai Y

Wed Dec 01 00:00:00 UTC 2021

PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.

Biochemical pharmacology

Xu Y,Denning KL,Lu Y

Fri Oct 01 00:00:00 UTC 2021

PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.

Free radical biology & medicine

Chen X,Xu Y,Denning KL,Grigore A,Lu Y

Tue Jun 01 00:00:00 UTC 2021

Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload.

Journal of molecular and cellular cardiology

Igaki Y,Tanno M,Sato T,Kouzu H,Ogawa T,Osanami A,Yano T,Kuno A,Miki T,Nakamura T,Miura T

Sat May 01 00:00:00 UTC 2021

Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.

International journal of molecular sciences

Wang Y,Kong W,Wang L,Zhang T,Huang B,Meng J,Yang B,Xie Z,Zhou H

Sun Oct 18 00:00:00 UTC 2020

Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P₂ and extended synaptotagmins.

Science China. Life sciences

Xiao J,Luo J,Hu A,Xiao T,Li M,Kong Z,Jiang L,Zhou Z,Liao Y,Xie C,Chu B,Miao H,Li B,Shi X,Song BL

Sun Sep 01 00:00:00 UTC 2019

Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis.

Free radical biology & medicine

Xu H,Li C,Mozziconacci O,Zhu R,Xu Y,Tang Y,Chen R,Huang Y,Holzbeierlein JM,Schöneich C,Huang J,Li B

Thu Aug 01 00:00:00 UTC 2019

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports

Li H,Zhao H,Hao S,Shang L,Wu J,Song C,Meyron-Holtz EG,Qiao T,Li K

Fri Mar 23 00:00:00 UTC 2018

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports

Li H,Zhao H,Hao S,Shang L,Wu J,Song C,Meyron-Holtz EG,Qiao T,Li K

Fri Mar 23 00:00:00 UTC 2018

Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia.

Scientific reports

Zhao H,Li H,Hao S,Chen J,Wu J,Song C,Zhang M,Qiao T,Li K

Tue Aug 29 00:00:00 UTC 2017

Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia.

Scientific reports

Zhao H,Li H,Hao S,Chen J,Wu J,Song C,Zhang M,Qiao T,Li K

Tue Aug 29 00:00:00 UTC 2017

Phosphorylation of Akt by SC79 Prevents Iron Accumulation and Ameliorates Early Brain Injury in a Model of Experimental Subarachnoid Hemorrhage.

Molecules (Basel, Switzerland)

Hao S,Song C,Shang L,Yu J,Qiao T,Li K

Thu Mar 10 00:00:00 UTC 2016

Phosphorylation of Akt by SC79 Prevents Iron Accumulation and Ameliorates Early Brain Injury in a Model of Experimental Subarachnoid Hemorrhage.

Molecules (Basel, Switzerland)

Hao S,Song C,Shang L,Yu J,Qiao T,Li K

Thu Mar 10 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody

View more View less

Gene Aliases: XDH; XDHA; XO; XOR; Xox-1; Xox1

View more View less

UniProt ID: (Human) P47989, (Rat) P22985, (Mouse) Q00519

View more View less

Entrez Gene ID: (Human) 7498, (Rat) 497811, (Mouse) 22436

View more View less

Function(s)

xanthine dehydrogenase activity xanthine oxidase activity iron ion binding electron carrier activity oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the aldehyde or oxo group of donors protein homodimerization activity molybdopterin cofactor binding flavin adenine dinucleotide binding 2 iron, 2 sulfur cluster binding UDP-N-acetylmuramate dehydrogenase activity oxidoreductase activity catalytic activity protein binding molybdenum ion binding metal ion binding iron-sulfur cluster binding

Process(es)

negative regulation of protein phosphorylation negative regulation of endothelial cell proliferation activation of cysteine-type endopeptidase activity involved in apoptotic process lactation xanthine catabolic process response to aluminum ion negative regulation of gene expression regulation of epithelial cell differentiation bone resorption negative regulation of endothelial cell differentiation negative regulation of protein kinase B signaling oxidation-reduction process positive regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of vasculogenesis purine nucleotide catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

XDH Polyclonal Antibody

XDH Antibody (55156-1-AP) in IHC (P)

Product Details

55156-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!