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Invitrogen
XDH Polyclonal Antibody
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FIGURE: 1 / 1
XDH Antibody (PA5-70621) in WB
Western blot was performed using Anti-XDH Polyclonal Antibody (Product # PA5-70621) and a 150 kDa band corresponding to Xanthine dehydrogenase/oxidase was observed in Small Intestine but not in Heart and Lung tissues which are reported to be low to negative for XDH expression. Additional uncharacterized bands (*) were observed across the panel. Whole-cell extracts (60 µg lysate) of Rat Small Intestine (Lane 1), Rat Heart (Lane 2), and Rat Lung (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX).... View More
Product Details
PA5-70621
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N-terminal region of rat XDH
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2691299
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody
Gene Aliases: Xdh; XOR
UniProt ID: (Rat) P22985
Entrez Gene ID: (Rat) 497811
xanthine dehydrogenase activity
xanthine oxidase activity
iron ion binding
UDP-N-acetylmuramate dehydrogenase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
protein homodimerization activity
molybdopterin cofactor binding
flavin adenine dinucleotide binding
2 iron, 2 sulfur cluster binding
negative regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
activation of cysteine-type endopeptidase activity involved in apoptotic process
lactation
xanthine catabolic process
response to aluminum ion
negative regulation of gene expression
regulation of epithelial cell differentiation
bone resorption
negative regulation of endothelial cell differentiation
negative regulation of protein kinase B signaling
oxidation-reduction process
positive regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of reactive oxygen species metabolic process
negative regulation of vasculogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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