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Proteintech
XPA Polyclonal Antibody
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Product Details
16462-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
XPA Fusion Protein Ag9536 (1-273 aa encoded by BC014965)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAADGALP EAAALEQPAE LPASVRASIE RKRQRALMLR QARLAARPYS ATAAAATGGM ANVKAAPKII DTGGGFILEE EEEEEQKIGK VVHQPGPVME FDYVICEECG KEFMDSYLMN HFDLPTCDNC RDADDKHKLI TKTEAKQEYL LKDCDLEKRE PPLKFIVKKN PHHSQWGDMK LYLKLQIVKR SLEVWGSQEA LEEAKEVRQE NREKMKQKKF DKKVKELRRA VRSSVWKRET IVHQHEYGPE ENLEDDMYRK TCTMCGHELT YEKM (1-273 aa encoded by BC014965)
Target Information
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; Xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A
Gene Aliases: AI573865; XP1; XPA; XPAC
UniProt ID: (Human) P23025, (Mouse) Q64267
Entrez Gene ID: (Human) 7507, (Mouse) 22590
DNA repair
nucleotide-excision repair
cellular response to DNA damage stimulus
response to oxidative stress
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
response to toxic substance
nucleotide-excision repair, DNA incision
multicellular organism growth
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
transcription-coupled nucleotide-excision repair
base-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
response to auditory stimulus
global genome nucleotide-excision repair
UV-damage excision repair
nucleotide-excision repair involved in interstrand cross-link repair
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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