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Proteintech
XPNPEP3 Polyclonal Antibody
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Product Details
15655-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
XPNPEP3 Fusion Protein Ag8007 (158-507 aa encoded by BC004989)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PSRELWDGP RSGTDGAIAL TGVDEAYTLE EFQHLLPKMK AETNMVWYDW MRPSHAQLHS DYMQPLTEAK AKSKNKVRGV QQLIQRLRLI KSPAEIERMQ IAGKLTSQAF IETMFTSKAP VEEAFLYAKF EFECRARGAD ILAYPPVVAG GNRSNTLHYV KNNQLIKDGE MVLLDGGCES SCYVSDITRT WPVNGRFTAP QAELYEAVLE IQRDCLALCF PGTSLENIYS MMLTLIGQKL KDLGIMKNIK ENNAFKAARK YCPHHVGHYL GMDVHDTPDM PRSLPLQPGM VITIEPGIYI PEDDKDAPEK FRGLGVRIED DVVVTQDSPL ILSADCPKEM NDIEQICSQA S (158-507 aa encoded by BC004989)
Target Information
XPNPEP3, also known as X-Prolyl Aminopeptidase 3, is a gene located on chromosome 22q that encodes an enzyme involved in the processing of mitochondrial matrix proteins. The enzyme is classified under the M24B subfamily of metallopeptidases, which specifically remove the N-terminal amino acid from oligopeptides where the penultimate residue is proline. XPNPEP3 is implicated in conditions such as cystic kidney disease and participates in TNF-TNFR2 cellular signaling pathways. Its yeast and plant homologs, like Icp55, perform similar functions by stabilizing proteins after import into the mitochondrial matrix. Mutations in XPNPEP3 are associated with defects in ciliary structure and function, contributing to the phenotypic spectrum seen in nephronophthisis-related ciliopathies (NPHP-RCs). The crystal structure of XPNPEP3 has been resolved at 1.65 A resolution, revealing its interaction with inhibitors such as apstatin. Furthermore, XPNPEP3 is identified as a transcriptional target of the canonical Wnt/beta-catenin signaling pathway, with elevated transcript levels observed in tumors exhibiting activated Wnt signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aminopeptidase P3; APP3; Intermediate Cleaving Peptidase 55; probable Xaa-Pro aminopeptidase 3; X-Pro aminopeptidase 3; X-prolyl aminopeptidase (aminopeptidase P) 3, putative; X-prolyl aminopeptidase 3, mitochondrial; Xaa-Pro aminopeptidase 3
Gene Aliases: APP3; E430012M05Rik; ICP55; NPHPL1; XPNPEP3
UniProt ID: (Human) Q9NQH7, (Rat) B5DEQ3, (Mouse) B7ZMP1
Entrez Gene ID: (Human) 63929, (Rat) 685823, (Mouse) 321003
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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