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Invitrogen
XPNPEP3 Polyclonal Antibody
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Product Details
PA5-51402
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human XPNPEP3. Recombinant protein control fragment (Product #RP-91390).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2649694
Product Specific Information
Immunogen sequence: THPHLLRPGE VTPGLSQVEY ALRRHKLMSL IQKEAQGQSG TDQTVVVLSN PTYYMSNDIP YTFHQDNNFL YLCGFQEPDS ILVLQSLPGK QLPSHKAILF VPRRDPSREL WDGPRSGTDG AIALTGVDEA YTLEEFQHLL PKMKAETNMV WYDWMRPSHA QLHSDYMQ
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.
Target Information
XPNPEP3, also known as X-Prolyl Aminopeptidase 3, is a gene located on chromosome 22q that encodes an enzyme involved in the processing of mitochondrial matrix proteins. The enzyme is classified under the M24B subfamily of metallopeptidases, which specifically remove the N-terminal amino acid from oligopeptides where the penultimate residue is proline. XPNPEP3 is implicated in conditions such as cystic kidney disease and participates in TNF-TNFR2 cellular signaling pathways. Its yeast and plant homologs, like Icp55, perform similar functions by stabilizing proteins after import into the mitochondrial matrix. Mutations in XPNPEP3 are associated with defects in ciliary structure and function, contributing to the phenotypic spectrum seen in nephronophthisis-related ciliopathies (NPHP-RCs). The crystal structure of XPNPEP3 has been resolved at 1.65 A resolution, revealing its interaction with inhibitors such as apstatin. Furthermore, XPNPEP3 is identified as a transcriptional target of the canonical Wnt/beta-catenin signaling pathway, with elevated transcript levels observed in tumors exhibiting activated Wnt signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aminopeptidase P3; APP3; Intermediate Cleaving Peptidase 55; probable Xaa-Pro aminopeptidase 3; X-Pro aminopeptidase 3; X-prolyl aminopeptidase (aminopeptidase P) 3, putative; X-prolyl aminopeptidase 3, mitochondrial; Xaa-Pro aminopeptidase 3
Gene Aliases: APP3; ICP55; NPHPL1; XPNPEP3
UniProt ID: (Human) Q9NQH7, (Rat) B5DEQ3
Entrez Gene ID: (Human) 63929, (Rat) 685823
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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