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Product Details
TA503304
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI5G2
Immunogen
Full length human recombinant protein of human XPNPEP3 produced in HEK293 cell.
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
XPNPEP3, also known as X-Prolyl Aminopeptidase 3, is a gene located on chromosome 22q that encodes an enzyme involved in the processing of mitochondrial matrix proteins. The enzyme is classified under the M24B subfamily of metallopeptidases, which specifically remove the N-terminal amino acid from oligopeptides where the penultimate residue is proline. XPNPEP3 is implicated in conditions such as cystic kidney disease and participates in TNF-TNFR2 cellular signaling pathways. Its yeast and plant homologs, like Icp55, perform similar functions by stabilizing proteins after import into the mitochondrial matrix. Mutations in XPNPEP3 are associated with defects in ciliary structure and function, contributing to the phenotypic spectrum seen in nephronophthisis-related ciliopathies (NPHP-RCs). The crystal structure of XPNPEP3 has been resolved at 1.65 A resolution, revealing its interaction with inhibitors such as apstatin. Furthermore, XPNPEP3 is identified as a transcriptional target of the canonical Wnt/beta-catenin signaling pathway, with elevated transcript levels observed in tumors exhibiting activated Wnt signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aminopeptidase P3; APP3; Intermediate Cleaving Peptidase 55; probable Xaa-Pro aminopeptidase 3; X-Pro aminopeptidase 3; X-prolyl aminopeptidase (aminopeptidase P) 3, putative; X-prolyl aminopeptidase 3, mitochondrial; Xaa-Pro aminopeptidase 3
Gene Aliases: APP3; E430012M05Rik; ICP55; NPHPL1; XPNPEP3
UniProt ID: (Human) Q9NQH7, (Rat) B5DEQ3, (Mouse) B7ZMP1
Entrez Gene ID: (Dog) 481237, (Human) 63929, (Rat) 685823, (Mouse) 321003
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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