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XRCC1 Polyclonal Antibody

XRCC1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

XRCC1 Antibody (21468-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 21468-1-AP (XRCC1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

21468-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XRCC1 Fusion Protein Ag15172 (284-633 aa encoded by BC023593)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TAPVPARAQ GAVTGKPRGE GTEPRRPRAG PEELGKILQG VVVVLSGFQN PFRSELRDKA LELGAKYRPD WTRDSTHLIC AFANTPKYSQ VLGLGGRIVR KEWVLDCHRM RRRLPSQRYL MAGPGSSSEE DEASHSGGSG DEAPKLPQKQ PQTKTKPTQA AGPSSPQKPP TPEETKAASP VLQEDIDIEG VQSEGQDNGA EDSGDTEDEL RRVAEQKEHR LPPGQEENGE DPYAGSTDEN TDSEEHQEPP DLPVPELPDF FQGKHFFLYG EFPGDERRKL IRYVTAFNGE LEDYMSDRVQ FVITAQEWDP SFEEALMDNP SLAFVRPRWI YSCNEKQKLL PHQLYGVVPQ A (284-633 aa encoded by BC023593)

Target Information

XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70 kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA ligase III-alpha.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.

Nucleic acids research

Yang M,Wang C,Zhou M,Bao L,Wang Y,Kumar A,Xing C,Luo W,Wang Y

Fri Jun 24 00:00:00 UTC 2022

Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM_2.5 from Beijing, China, in Winter.

International journal of environmental research and public health

Niu BY,Li WK,Li JS,Hong QH,Khodahemmati S,Gao JF,Zhou ZX

Mon Jul 06 00:00:00 UTC 2020

XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer.

Frontiers in molecular biosciences

Wu Z,Miao X,Zhang Y,Li D,Zou Q,Yuan Y,Liu R,Yang Z

Mon Sep 28 00:00:00 UTC 2020

XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer.

Frontiers in molecular biosciences

Wu Z,Miao X,Zhang Y,Li D,Zou Q,Yuan Y,Liu R,Yang Z

Mon Sep 28 00:00:00 UTC 2020

Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.

Journal of cellular and molecular medicine

Gao X,Wang J,Li M,Wang J,Lv J,Zhang L,Sun C,Ji J,Yang W,Zhao Z,Mao W

Tue Oct 01 00:00:00 UTC 2019

Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer.

Molecular therapy : the journal of the American Society of Gene Therapy

Wang X,Zhang H,Bai M,Ning T,Ge S,Deng T,Liu R,Zhang L,Ying G,Ba Y

Wed Mar 07 00:00:00 UTC 2018

Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer.

Molecular therapy : the journal of the American Society of Gene Therapy

Wang X,Zhang H,Bai M,Ning T,Ge S,Deng T,Liu R,Zhang L,Ying G,Ba Y

Wed Mar 07 00:00:00 UTC 2018

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: DNA repair protein XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1

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Gene Aliases: RCC; Xrcc-1; XRCC1

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UniProt ID: (Human) P18887, (Mouse) Q60596

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Entrez Gene ID: (Human) 7515, (Mouse) 22594

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Function(s)

damaged DNA binding DNA ligase activity protein binding enzyme binding

Process(es)

single strand break repair double-strand break repair via homologous recombination response to hypoxia transcription-coupled nucleotide-excision repair base-excision repair base-excision repair, DNA ligation nucleotide-excision repair, DNA gap filling response to organic substance response to drug DNA repair cellular response to DNA damage stimulus hippocampus development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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XRCC1 Polyclonal Antibody

XRCC1 Antibody (21468-1-AP) in ICC/IF

Product Details

21468-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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