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Proteintech
XRCC4 Monoclonal Antibody (3E5D2)
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Product Details
66621-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3E5D2
Immunogen
XRCC4 Fusion Protein Ag8807 (6-310 aa encoded by BC005259)
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SRIHLVSEP SITHFLQVSW EKTLESGFVI TLTDGHSAWT GTVSESEISQ EADDMAMEKG KYVGELRKAL LSGAGPADVY TFNFSKESCY FFFEKNLKDV SFRLGSFNLE KVENPAEVIR ELICYCLDTI AENQAKNEHL QKENERLLRD WNDVQGRFEK CVSAKEALET DLYKRFILVL NEKKTKIRSL HNKLLNAAQE REKDIKQEGE TAICSEMTAD RDPVYDESTD EESENQTDLS GLASAAVSKD DSIISSLDVT DIAPSRKRRQ RMQRNLGTEP KMAPQENQLQ EKEKGRKKET SEKEAV (6-310 aa encoded by B C005259)
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA repair protein XRCC4; hXRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4
Gene Aliases: SSMED; XRCC4
UniProt ID: (Human) Q13426
Entrez Gene ID: (Human) 7518
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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