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XRCC5/Ku80 Polyclonal Antibody

View all (51) Ku80 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (15)

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF)

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

XRCC5/Ku80 Antibody (16389-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using XRCC5 antibody 16389-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF)

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Immunoprecipitation (IP)

Product Image Gallery

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using XRCC5 antibody 16389-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 40x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 10x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 40x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 10x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:100 (under 40x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:100 (under 10x lens).

XRCC5/Ku80 Antibody in Western Blot (WB) — Human liver tissue were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — K-562 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — A431 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — WB result of Ku80 antibody (16389-1-AP, 1:4000) with si-Control and si-Ku80 transfected HEK-293 cells.

XRCC5/Ku80 Antibody in Immunoprecipitation (IP) — IP result of anti-XRCC5/Ku80 (IP:16389-1-AP, 4ug; Detection:16389-1-AP 1:1000) with HEK-293 cells lysate 1200ug.

Product Details

16389-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 6 publications 6 publications

ChIP assay (ChIP)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XRCC5/Ku80 Fusion Protein Ag9454

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.

The FEBS journal

Wei Y,Xiao G,Xu H,Sun X,Shi Y,Wang F,Kang J,Peng J,Zhou F

Sat Jul 01 00:00:00 UTC 2023

LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.

Journal of ovarian research

Dey G,Bharti R,Braley C,Alluri R,Esakov E,Crean-Tate K,McCrae K,Joehlin-Price A,Rose PG,Lathia J,Gong Z,Reizes O

Tue Jun 27 00:00:00 UTC 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

Tue Jul 25 00:00:00 UTC 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

Tue Jul 25 00:00:00 UTC 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

Tue Jul 25 00:00:00 UTC 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

Tue Jul 25 00:00:00 UTC 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

Tue Jul 25 00:00:00 UTC 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

Tue Jul 25 00:00:00 UTC 2023

Screening and characterization of myositis-related autoantibodies in COVID-19 patients.

Clinical and translational science

Teo KF,Chen DY,Hsu JT,Lai YH,Chang CK,Hsueh PR,Lan JL,Hsu JL

Sun Jan 01 00:00:00 UTC 2023

Screening and characterization of myositis-related autoantibodies in COVID-19 patients.

Clinical and translational science

Teo KF,Chen DY,Hsu JT,Lai YH,Chang CK,Hsueh PR,Lan JL,Hsu JL

Sun Jan 01 00:00:00 UTC 2023

Proteomic Analysis of Vero Cells Infected with Pseudorabies Virus.

Viruses

Yang X,Xu S,Chen D,Jiang R,Kang H,Ge X,Zhou L,Han J,Zhang Y,Guo X,Yang H

Mon Apr 04 00:00:00 UTC 2022

ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.

Frontiers in oncology

Wen X,Chen S,Chen X,Qiu H,Wang W,Zhang N,Liu W,Wang T,Ding X,Zhang L

Mon Mar 11 00:00:00 UTC 2024

WASH interacts with Ku to regulate DNA double-stranded break repair.

iScience

Wang T,Du XH,Hong Y,Hong X,Fan L,Zhou JW,Sun H,Ge J,Billadeau DD,Deng ZH

Fri Jan 21 00:00:00 UTC 2022

WASH interacts with Ku to regulate DNA double-stranded break repair.

iScience

Wang T,Du XH,Hong Y,Hong X,Fan L,Zhou JW,Sun H,Ge J,Billadeau DD,Deng ZH

Fri Jan 21 00:00:00 UTC 2022

circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.

Cell reports

Li Q,Yao H,Wang Y,Wu Y,Thorne RF,Zhu Y,Wu M,Liu L

Tue Nov 22 00:00:00 UTC 2022

circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.

Cell reports

Li Q,Yao H,Wang Y,Wu Y,Thorne RF,Zhu Y,Wu M,Liu L

Tue Nov 22 00:00:00 UTC 2022

Acquired temozolomide resistance in MGMT^low gliomas is associated with regulation of homologous recombination repair by ROCK2.

Cell death & disease

Zhang X,Li T,Yang M,Du Q,Wang R,Fu B,Tan Y,Cao M,Chen Y,Wang Q,Hu R

Thu Feb 10 00:00:00 UTC 2022

Acquired temozolomide resistance in MGMT^low gliomas is associated with regulation of homologous recombination repair by ROCK2.

Cell death & disease

Zhang X,Li T,Yang M,Du Q,Wang R,Fu B,Tan Y,Cao M,Chen Y,Wang Q,Hu R

Thu Feb 10 00:00:00 UTC 2022

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.

Cell death & disease

Guo Z,Wang YH,Xu H,Yuan CS,Zhou HH,Huang WH,Wang H,Zhang W

Mon Jan 04 00:00:00 UTC 2021

OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.

Cell death & disease

Cui Y,Xie R,Zhang X,Liu Y,Hu Y,Li Y,Liu X,Yu X,Wu C

Wed Jun 16 00:00:00 UTC 2021

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.

Cell reports

Tichy ED,Ma N,Sidibe D,Loro E,Kocan J,Chen DZ,Khurana TS,Hasty P,Mourkioti F

Tue May 11 00:00:00 UTC 2021

Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca²⁺]_m-PDP1-PDH-histone acetylation retrograde signaling.

Cell death & disease

Shi Y,Wang Y,Jiang H,Sun X,Xu H,Wei X,Wei Y,Xiao G,Song Z,Zhou F

Mon Sep 06 00:00:00 UTC 2021

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma.

Oncology letters

Lee IN,Yang JT,Huang C,Huang HC,Wu YP,Chen JC

Tue Jun 01 00:00:00 UTC 2021

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma.

Oncology letters

Lee IN,Yang JT,Huang C,Huang HC,Wu YP,Chen JC

Tue Jun 01 00:00:00 UTC 2021

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma.

Oncology letters

Lee IN,Yang JT,Huang C,Huang HC,Wu YP,Chen JC

Tue Jun 01 00:00:00 UTC 2021

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma.

Oncology letters

Lee IN,Yang JT,Huang C,Huang HC,Wu YP,Chen JC

Tue Jun 01 00:00:00 UTC 2021

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.

Journal of Cancer

Wang L,Huang Y,Liu C,Guo M,Ma Z,He J,Wang A,Sun X,Liu Z

Mon Jan 11 00:00:00 UTC 2021

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.

Journal of Cancer

Wang L,Huang Y,Liu C,Guo M,Ma Z,He J,Wang A,Sun X,Liu Z

Mon Jan 11 00:00:00 UTC 2021

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.

Journal of Cancer

Wang L,Huang Y,Liu C,Guo M,Ma Z,He J,Wang A,Sun X,Liu Z

Mon Jan 11 00:00:00 UTC 2021

Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer.

Journal of materials chemistry. B

Li S,Sun W,Luo Y,Gao Y,Jiang X,Yuan C,Han L,Cao K,Gong Y,Xie C

Wed Jun 16 00:00:00 UTC 2021

Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.

The Journal of biological chemistry

Cao C,Han P,Liu L,Tang Y,Tian S,Zhang K,Shi L,Liu Z,Zhuo D,Ge W,Gong W

Wed Sep 01 00:00:00 UTC 2021

Cytoplasmic DNA sensing by KU complex in aged CD4⁺ T cell potentiates T cell activation and aging-related autoimmune inflammation.

Immunity

Wang Y,Fu Z,Li X,Liang Y,Pei S,Hao S,Zhu Q,Yu T,Pei Y,Yuan J,Ye J,Fu J,Xu J,Hong J,Yang R,Hou H,Huang X,Peng C,Zheng M,Xiao Y

Tue Apr 13 00:00:00 UTC 2021

Cytoplasmic DNA sensing by KU complex in aged CD4⁺ T cell potentiates T cell activation and aging-related autoimmune inflammation.

Immunity

Wang Y,Fu Z,Li X,Liang Y,Pei S,Hao S,Zhu Q,Yu T,Pei Y,Yuan J,Ye J,Fu J,Xu J,Hong J,Yang R,Hou H,Huang X,Peng C,Zheng M,Xiao Y

Tue Apr 13 00:00:00 UTC 2021

Cytoplasmic DNA sensing by KU complex in aged CD4⁺ T cell potentiates T cell activation and aging-related autoimmune inflammation.

Immunity

Wang Y,Fu Z,Li X,Liang Y,Pei S,Hao S,Zhu Q,Yu T,Pei Y,Yuan J,Ye J,Fu J,Xu J,Hong J,Yang R,Hou H,Huang X,Peng C,Zheng M,Xiao Y

Tue Apr 13 00:00:00 UTC 2021

Cytoplasmic DNA sensing by KU complex in aged CD4⁺ T cell potentiates T cell activation and aging-related autoimmune inflammation.

Immunity

Wang Y,Fu Z,Li X,Liang Y,Pei S,Hao S,Zhu Q,Yu T,Pei Y,Yuan J,Ye J,Fu J,Xu J,Hong J,Yang R,Hou H,Huang X,Peng C,Zheng M,Xiao Y

Tue Apr 13 00:00:00 UTC 2021

DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.

Oncology reports

Luo W,Zhang H,Liang X,Xia R,Deng H,Yi Q,Lv L,Qian L

Fri May 01 00:00:00 UTC 2020

Increasing CRISPR/Cas9-mediated homology-directed DNA repair by histone deacetylase inhibitors.

The international journal of biochemistry & cell biology

Li G,Zhang X,Wang H,Liu D,Li Z,Wu Z,Yang H

Sat Aug 01 00:00:00 UTC 2020

Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.

Human cell

Ren X,Tang Y,Sun J,Feng J,Chen L,Chen H,Zeng S,Chen C,Li X,Zhu H,Zeng Z

Sun Apr 01 00:00:00 UTC 2018

Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.

Human cell

Ren X,Tang Y,Sun J,Feng J,Chen L,Chen H,Zeng S,Chen C,Li X,Zhu H,Zeng Z

Sun Apr 01 00:00:00 UTC 2018

Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes.

Scientific reports

Martin JH,Bromfield EG,Aitken RJ,Lord T,Nixon B

Tue Jun 26 00:00:00 UTC 2018

Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes.

Scientific reports

Martin JH,Bromfield EG,Aitken RJ,Lord T,Nixon B

Tue Jun 26 00:00:00 UTC 2018

UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.

Oncogene

Hu L,Li X,Liu Q,Xu J,Ge H,Wang Z,Wang H,Wang Z,Shi C,Xu X,Huang J,Lin Z,Pieper RO,Weng C

Thu Feb 23 00:00:00 UTC 2017

UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.

Oncogene

Hu L,Li X,Liu Q,Xu J,Ge H,Wang Z,Wang H,Wang Z,Shi C,Xu X,Huang J,Lin Z,Pieper RO,Weng C

Thu Feb 23 00:00:00 UTC 2017

Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.

Journal of Cancer

Wang Y,Hu L,Zhang X,Zhao H,Xu H,Wei Y,Jiang H,Xie C,Zhou Y,Zhou F

Thu Oct 01 00:00:00 UTC 2020

Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.

Journal of Cancer

Wang Y,Hu L,Zhang X,Zhao H,Xu H,Wei Y,Jiang H,Xie C,Zhou Y,Zhou F

Thu Oct 01 00:00:00 UTC 2020

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages.

Oncotarget

Qi H,Jiang Z,Wang C,Yang Y,Li L,He H,Yu Z

Tue Apr 25 00:00:00 UTC 2017

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages.

Oncotarget

Qi H,Jiang Z,Wang C,Yang Y,Li L,He H,Yu Z

Tue Apr 25 00:00:00 UTC 2017

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; HGNC:12833; Ku autoantigen protein p86 homolog; Ku autoantigen, 80kDa; Ku p80; Ku-80; Ku-86; Ku80; Ku86; Ku86 autoantigen related protein 1; Lupu; lupus; Lupus Ku autoantigen protein p86; Nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5

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Gene Aliases: AI314015; G22P2; KARP-1; KARP1; KU80; Ku86; KUB2; NFIV; XRCC5

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UniProt ID: (Human) P13010, (Mouse) P27641

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Entrez Gene ID: (Human) 7520, (Mouse) 22596

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DNA binding damaged DNA binding double-stranded DNA binding double-stranded telomeric DNA binding ATP-dependent DNA helicase activity protein binding ATP binding protein C-terminus binding ubiquitin protein ligase binding telomeric DNA binding transcription regulatory region DNA binding poly(A) RNA binding macromolecular complex binding 5'-deoxyribose-5-phosphate lyase activity nucleotide binding helicase activity hydrolase activity hydrolase activity, acting on acid anhydrides

telomere maintenance double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination transcription, DNA-templated cell proliferation positive regulation of type I interferon production DNA duplex unwinding negative regulation of transcription, DNA-templated regulation of smooth muscle cell proliferation positive regulation of neurogenesis hematopoietic stem cell differentiation cellular response to gamma radiation cellular response to X-ray establishment of integrated proviral latency negative regulation of t-circle formation DNA repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus cellular hyperosmotic salinity response

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