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YEATS2 Polyclonal Antibody

YEATS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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YEATS2 Antibody (24717-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 24717-1-AP ( YEATS2 Antibody) at dilution of 1:50 (under 40x lens).

YEATS2 Antibody in Immunoprecipitation (IP)

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Product Details

24717-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

YEATS2 Fusion Protein Ag20134 (1066-1422 aa encoded by BC150273)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VQTILMPVN KVVQSFSTSK PPAILPVAAP TPVVPSSAPA AVAKVKTEPE TPGPSCLSQE GQTAVKTEES SELGNYVIKI DHLETIQQLL TAVVKKIPLI TAKSEDASCF SAKSVEQYYG WNIGKRRAAE WQRAMTMRKV LQEILEKNPR FHHLTPLKTK HIAHWCRCHG YTPPDPESLR NDGDSIEDVL TQIDSEPECP SSFSSADNLC RKLEDLQQFQ KREPENEEEV DILSLSEPVK INIKKEQEEK QEEVKFYLPP TPGSEFIGDV TQKIGITLQP VALHRNVYAS VVEDMILKAT EQLVNDILRQ ALAVGYQTAS HNRIPKEITV SNIHQAICNI PFLDFLTNKH MGILNEDQ (1066-1422 aa encoded by BC150273)

Target Information

The YEATS domain-containing protein 2 (YEATS2) is a nuclear protein that is phosphorylated upon DNA damage by ATM or ATR and contains 1 YEATS domain. The gene encoding YEATS2 resides on chromosome 3, which contains about 214 million bases encoding over 1, 100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.

Cell biology and toxicology

Sheng H,Zheng F,Lan T,Chen HF,Xu CY,Wang SW,Weng YY,Xu LF,Zhang F

Thu Jun 01 00:00:00 UTC 2023

YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.

Cell biology and toxicology

Sheng H,Zheng F,Lan T,Chen HF,Xu CY,Wang SW,Weng YY,Xu LF,Zhang F

Thu Jun 01 00:00:00 UTC 2023

YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.

Cell biology and toxicology

Sheng H,Zheng F,Lan T,Chen HF,Xu CY,Wang SW,Weng YY,Xu LF,Zhang F

Thu Jun 01 00:00:00 UTC 2023

Cinobufacini retards progression of pancreatic ductal adenocarcinoma through targeting YEATS2/TAK1/NF-κB axis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Lan T,Chen HF,Zheng F,Huang H,Wu Q,Fan XY,Wang SW,Zhang F

Sun Jan 01 00:00:00 UTC 2023

Cinobufacini retards progression of pancreatic ductal adenocarcinoma through targeting YEATS2/TAK1/NF-κB axis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Lan T,Chen HF,Zheng F,Huang H,Wu Q,Fan XY,Wang SW,Zhang F

Sun Jan 01 00:00:00 UTC 2023

Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway.

Cancers

Liu X,Hu Y,Li C,Chen J,Liu X,Shen Y,Xu Y,Chen W,Xu X

Mon Mar 20 00:00:00 UTC 2023

Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.

Signal transduction and targeted therapy

Xi Y,Lin Y,Guo W,Wang X,Zhao H,Miao C,Liu W,Liu Y,Liu T,Luo Y,Fan W,Lin A,Chen Y,Sun Y,Ma Y,Niu X,Zhong C,Tan W,Zhou M,Su J,Wu C,Lin D

Fri Feb 25 00:00:00 UTC 2022

YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.

Journal of cellular physiology

Zeng Z,Lei S,He Z,Chen T,Jiang J

Mon Mar 01 00:00:00 UTC 2021

YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.

Journal of cellular physiology

Zeng Z,Lei S,He Z,Chen T,Jiang J

Mon Mar 01 00:00:00 UTC 2021

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

Nature communications

Mi W,Guan H,Lyu J,Zhao D,Xi Y,Jiang S,Andrews FH,Wang X,Gagea M,Wen H,Tora L,Dent SYR,Kutateladze TG,Li W,Li H,Shi X

Fri Oct 20 00:00:00 UTC 2017

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

Nature communications

Mi W,Guan H,Lyu J,Zhao D,Xi Y,Jiang S,Andrews FH,Wang X,Gagea M,Wen H,Tora L,Dent SYR,Kutateladze TG,Li W,Li H,Shi X

Fri Oct 20 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: YEATS domain-containing protein 2; YETS2

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Gene Aliases: KIAA1197; YEATS2

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UniProt ID: (Human) Q9ULM3

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Entrez Gene ID: (Human) 55689

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Function(s)

protein binding TBP-class protein binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter histone H3 acetylation negative regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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YEATS2 Polyclonal Antibody

YEATS2 Antibody (24717-1-AP) in IHC (P)

Product Details

24717-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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