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Invitrogen
YES1 Polyclonal Antibody
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Product Details
PA5-80243
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Yes1 (7-35aa KENKSPAIKYRPENTPEPVSTSVSHYGAE).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2747357
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human U20S whole cell, human CACO-2 whole cell, human A431 whole cell, human HepG2 whole cell, human MCF-7 whole cell, human PC-3 whole cell. IHC: human mammary cancer tissue.
Target Information
YES1 is a recombinant human protein kinase that is a member of the SRC family of non-receptor tyrosine kinases and is the cellular homolog of the Yamaguchi sarcoma virus oncogene. It is involved in the regulation of cell growth and survival, including roles in apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-Src; cellular yes-1 protein; EC 2.7.10.2; p60-Src; p61-Yes; pp60c-src; Proto-oncogene c-Yes; proto-oncogene tyrosine-protein kinase YES; Tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Yamaguchi sarcoma oncogene; YES1 proto-oncogene, Src family tyrosine kinase
Gene Aliases: c-yes; HsT441; P61-YES; YES; YES1
UniProt ID: (Human) P07947
Entrez Gene ID: (Human) 7525
cellular protein modification process
transmembrane receptor protein tyrosine kinase signaling pathway
glucose transport
cell differentiation
T cell costimulation
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of cell proliferation
regulation of vascular permeability
innate immune response
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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