Proteintech

YTHDF1 Polyclonal Antibody

YTHDF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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YTHDF1 Antibody (17479-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue slide using (Product # 17479-1-AP) YTHDF1 antibody at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

YTHDF1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

YTHDF1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17479-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 142 publications 142 publications

Immunohistochemistry (IHC)

View 26 publications 26 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 23 publications 23 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 7 publications 7 publications

RNA Immunoprecipitation (RIP)

View 41 publications 41 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

YTHDF1 Fusion Protein Ag11509 (210-559 aa encoded by BC050284)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VALTGVLSG NGGTNVNMPV SKPTSWAAIA SKPAKPQPKM KTKSGPVMGG GLPPPPIKHN MDIGTWDNKG PVPKAPVPQQ APSPQAAPQP QQVAQPLPAQ PPALAQPQYQ SPQQPPQTRW VAPRNRNAAF GQSGGAGSDS NSPGNVQPNS APSVESHPVL EKLKAAHSYN PKEFEWNLKS GRVFIIKSYS EDDIHRSIKY SIWCSTEHGN KRLDSAFRCM SSKGPVYLLF SVNGSGHFCG VAEMKSPVDY GTSAGVWSQD KWKGKFDVQW IFVKDVPNNQ LRHIRLENND NKPVTNSRDT QEVPLEKAKQ VLKIISSYKH TTSIFDDFAH YEKRQEEEEV VRKERQSRNK Q (210-559 aa encoded by BC050284)

Target Information

Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts, thereby promoting their translation. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Cellular signalling

Yu Z,Zheng L,Geng Y,Zhang Y,Wang Y,You G,Cai M,Li M,Cheng X,Zan J

Fri Sep 01 00:00:00 UTC 2023

YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.

Journal of virology

Hesser CR,Walsh D

Thu Mar 30 00:00:00 UTC 2023

Pseudorabies virus exploits N⁶-methyladenosine modification to promote viral replication.

Frontiers in microbiology

Yu PL,Wu R,Cao SJ,Wen YP,Huang XB,Zhao S,Lang YF,Zhao Q,Lin JC,Du SY,Yu SM,Yan QG

Fri Feb 24 00:00:00 UTC 2023

m⁶A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.

Cancer letters

Benavides-Serrato A,Saunders JT,Kumar S,Holmes B,Benavides KE,Bashir MT,Nishimura RN,Gera J

Sun May 28 00:00:00 UTC 2023

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Wang X,Li X,Yang P,Qin X,Yu J,Cheng Y,Zhang G,Tang L

Thu Jun 01 00:00:00 UTC 2023

Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.

Cerebral cortex (New York, N.Y. : 1991)

Li SJ,Zhang LX,Zou GJ,Ma MH,Zhou SF,Lu XY,Li F,Li CQ

Mon Feb 20 00:00:00 UTC 2023

Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.

Cerebral cortex (New York, N.Y. : 1991)

Li SJ,Zhang LX,Zou GJ,Ma MH,Zhou SF,Lu XY,Li F,Li CQ

Mon Feb 20 00:00:00 UTC 2023

Newcastle disease virus activates methylation-related enzymes to reprogram m⁶A methylation in infected cells.

Veterinary microbiology

Yuan W,Hou Y,Wang Q,Lv T,Ren J,Fan L,Cai J,Xiang B,Lin Q,Liao M,Ding C,Chen L,Ren T

Thu Jun 01 00:00:00 UTC 2023

RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.

Environmental pollution (Barking, Essex : 1987)

Li JZ,Zhou SM,Yuan WB,Chen HQ,Zeng Y,Fan J,Zhang Z,Wang N,Cao J,Liu WB

Wed Mar 15 00:00:00 UTC 2023

N⁶-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Nature communications

Wang X,Ding Y,Li R,Zhang R,Ge X,Gao R,Wang M,Huang Y,Zhang F,Zhao B,Liao W,Du J

Thu Mar 02 00:00:00 UTC 2023

YTHDF2 in dentate gyrus is the m⁶A reader mediating m⁶A modification in hippocampus-dependent learning and memory.

Molecular psychiatry

Zhuang M,Geng X,Han P,Che P,Liang F,Liu C,Yang L,Yu J,Zhang Z,Dong W,Ji SJ

Sat Apr 01 00:00:00 UTC 2023

YTHDF2 in dentate gyrus is the m⁶A reader mediating m⁶A modification in hippocampus-dependent learning and memory.

Molecular psychiatry

Zhuang M,Geng X,Han P,Che P,Liang F,Liu C,Yang L,Yu J,Zhang Z,Dong W,Ji SJ

Sat Apr 01 00:00:00 UTC 2023

N⁶-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.

Ecotoxicology and environmental safety

Ji D,Hu C,Ning J,Ying X,Zhang H,Zhang B,Liu B,Liu Q,Ji W,Zhang R

Sat Apr 01 00:00:00 UTC 2023

O-GlcNAcylation promotes the cytosolic localization of the m⁶A reader YTHDF1 and colorectal cancer tumorigenesis.

The Journal of biological chemistry

Li J,Ahmad M,Sang L,Zhan Y,Wang Y,Yan Y,Liu Y,Mi W,Lu M,Dai Y,Zhang R,Dong MQ,Yang YG,Wang X,Sun J,Li J

Thu Jun 01 00:00:00 UTC 2023

O-GlcNAcylation promotes the cytosolic localization of the m⁶A reader YTHDF1 and colorectal cancer tumorigenesis.

The Journal of biological chemistry

Li J,Ahmad M,Sang L,Zhan Y,Wang Y,Yan Y,Liu Y,Mi W,Lu M,Dai Y,Zhang R,Dong MQ,Yang YG,Wang X,Sun J,Li J

Thu Jun 01 00:00:00 UTC 2023

YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.

Cell reports

Fang Q,Tian GG,Wang Q,Liu M,He L,Li S,Wu J

Tue Apr 25 00:00:00 UTC 2023

Epitranscriptic regulation of HRAS by N⁶-methyladenosine drives tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Pan Y,Gu Y,Liu T,Zhang Q,Yang F,Duan L,Cheng S,Zhu X,Xi Y,Chang X,Ye Q,Gao S

Tue Apr 04 00:00:00 UTC 2023

Epitranscriptic regulation of HRAS by N⁶-methyladenosine drives tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Pan Y,Gu Y,Liu T,Zhang Q,Yang F,Duan L,Cheng S,Zhu X,Xi Y,Chang X,Ye Q,Gao S

Tue Apr 04 00:00:00 UTC 2023

Epitranscriptic regulation of HRAS by N⁶-methyladenosine drives tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Pan Y,Gu Y,Liu T,Zhang Q,Yang F,Duan L,Cheng S,Zhu X,Xi Y,Chang X,Ye Q,Gao S

Tue Apr 04 00:00:00 UTC 2023

Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Ai S,Li D,Gu X,Xu Y,Wang Y,Wang HL,Chen XT

Tue Aug 01 00:00:00 UTC 2023

YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m⁶A/mRNA pathway in spermatogonial stem cells/progenitors.

Toxicology letters

Li T,Zheng Y,Wu Z,Guo M,Liu R,Zeng W,Lv Y

Wed Mar 15 00:00:00 UTC 2023

Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice.

PLoS biology

Yin H,Ju Z,Zheng M,Zhang X,Zuo W,Wang Y,Ding X,Zhang X,Peng Y,Li J,Yang A,Zhang R

Wed Mar 01 00:00:00 UTC 2023

Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice.

PLoS biology

Yin H,Ju Z,Zheng M,Zhang X,Zuo W,Wang Y,Ding X,Zhang X,Peng Y,Li J,Yang A,Zhang R

Wed Mar 01 00:00:00 UTC 2023

The m⁶A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m⁶A-Dependent Manner.

Pharmaceuticals (Basel, Switzerland)

Diao H,Tan H,Hu Y,Wang R,Cai P,Huang B,Shao X,Yan M,Yin C,Zhang Y

Wed Jan 25 00:00:00 UTC 2023

The m⁶A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m⁶A-Dependent Manner.

Pharmaceuticals (Basel, Switzerland)

Diao H,Tan H,Hu Y,Wang R,Cai P,Huang B,Shao X,Yan M,Yin C,Zhang Y

Wed Jan 25 00:00:00 UTC 2023

The m⁶A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m⁶A-Dependent Manner.

Pharmaceuticals (Basel, Switzerland)

Diao H,Tan H,Hu Y,Wang R,Cai P,Huang B,Shao X,Yan M,Yin C,Zhang Y

Wed Jan 25 00:00:00 UTC 2023

Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.

Nature communications

Yan S,Zhou X,Wu C,Gao Y,Qian Y,Hou J,Xie R,Han B,Chen Z,Wei S,Gao X

Mon Mar 13 00:00:00 UTC 2023

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.

Cancer research

Hong YG,Yang Z,Chen Y,Liu T,Zheng Y,Zhou C,Wu GC,Chen Y,Xia J,Wen R,Liu W,Zhao Y,Chen J,Gao X,Chen Z

Wed Mar 15 00:00:00 UTC 2023

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.

Cancer research

Hong YG,Yang Z,Chen Y,Liu T,Zheng Y,Zhou C,Wu GC,Chen Y,Xia J,Wen R,Liu W,Zhao Y,Chen J,Gao X,Chen Z

Wed Mar 15 00:00:00 UTC 2023

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.

Cancer research

Hong YG,Yang Z,Chen Y,Liu T,Zheng Y,Zhou C,Wu GC,Chen Y,Xia J,Wen R,Liu W,Zhao Y,Chen J,Gao X,Chen Z

Wed Mar 15 00:00:00 UTC 2023

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.

Cancer research

Hong YG,Yang Z,Chen Y,Liu T,Zheng Y,Zhou C,Wu GC,Chen Y,Xia J,Wen R,Liu W,Zhao Y,Chen J,Gao X,Chen Z

Wed Mar 15 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

AS3MT facilitates NLRP3 inflammasome activation by m⁶A modification during arsenic-induced hepatic insulin resistance.

Cell biology and toxicology

Qiu T,Wu C,Yao X,Han Q,Wang N,Yuan W,Zhang J,Shi Y,Jiang L,Liu X,Yang G,Sun X

Sun Oct 01 00:00:00 UTC 2023

Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m⁶A-YTHDF1-dependent manner.

Journal of animal science and biotechnology

Gong H,Gong T,Liu Y,Wang Y,Wang X

Thu Apr 06 00:00:00 UTC 2023

Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.

Environmental pollution (Barking, Essex : 1987)

Yang F,Zhang A

Sun Jan 01 00:00:00 UTC 2023

METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.

International journal of molecular sciences

Li D,He J,Fang C,Zhang Y,He M,Zhang Z,Hou J,Xu Q

Wed Jan 11 00:00:00 UTC 2023

METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.

International journal of molecular sciences

Li D,He J,Fang C,Zhang Y,He M,Zhang Z,Hou J,Xu Q

Wed Jan 11 00:00:00 UTC 2023

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.

Journal of experimental & clinical cancer research : CR

Wei W,Zhang ZY,Shi B,Cai Y,Zhang HS,Sun CL,Fei YF,Zhong W,Zhang S,Wang C,He B,Jiang GM,Wang H

Tue Jun 20 00:00:00 UTC 2023

PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.

Carcinogenesis

Chen W,He Q,Liu J,Li N,Xiao K,Chen H

Sat Jun 24 00:00:00 UTC 2023

PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.

Carcinogenesis

Chen W,He Q,Liu J,Li N,Xiao K,Chen H

Sat Jun 24 00:00:00 UTC 2023

PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.

Carcinogenesis

Chen W,He Q,Liu J,Li N,Xiao K,Chen H

Sat Jun 24 00:00:00 UTC 2023

m⁶A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.

Signal transduction and targeted therapy

Liu Y,Song R,Zhao L,Lu Z,Li Y,Zhan X,Lu F,Yang J,Niu Y,Cao X

Wed Jun 29 00:00:00 UTC 2022

ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.

Clinical and translational medicine

Li A,Cao C,Gan Y,Wang X,Wu T,Zhang Q,Liu Y,Yao L,Zhang Q

Wed Jun 01 00:00:00 UTC 2022

The m⁶A methyltransferase METTL3 regulates muscle maintenance and growth in mice.

Nature communications

Petrosino JM,Hinger SA,Golubeva VA,Barajas JM,Dorn LE,Iyer CC,Sun HL,Arnold WD,He C,Accornero F

Mon Jan 10 00:00:00 UTC 2022

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.

Journal of neuroinflammation

Ouyang H,Zhang J,Chi D,Zhang K,Huang Y,Huang J,Huang W,Bai X

Thu Dec 22 00:00:00 UTC 2022

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.

Journal of neuroinflammation

Ouyang H,Zhang J,Chi D,Zhang K,Huang Y,Huang J,Huang W,Bai X

Thu Dec 22 00:00:00 UTC 2022

The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.

The journal of gene medicine

Li Y,Zhang X,Cai J,Ren L,Liu B,Wu M,Lu W,Li R,Zhang C,Huang C,Tong J,Liu A,Zheng Y,Ren D,Guo Y,Huang Y

Tue Feb 01 00:00:00 UTC 2022

m⁶A regulation of cortical and retinal neurogenesis is mediated by the redundant m⁶A readers YTHDFs.

iScience

Niu F,Che P,Yang Z,Zhang J,Yang L,Zhuang M,Ou X,Ji SJ

Fri Sep 16 00:00:00 UTC 2022

m⁶A regulation of cortical and retinal neurogenesis is mediated by the redundant m⁶A readers YTHDFs.

iScience

Niu F,Che P,Yang Z,Zhang J,Yang L,Zhuang M,Ou X,Ji SJ

Fri Sep 16 00:00:00 UTC 2022

Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.

Frontiers in oncology

Koh YW,Han JH,Haam S,Lee HW

Sat Dec 10 00:00:00 UTC 2022

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Frontiers in immunology

Li Z,Teng M,Jiang Y,Zhang L,Luo X,Liao Y,Yang B

Fri Apr 22 00:00:00 UTC 2022

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Frontiers in immunology

Li Z,Teng M,Jiang Y,Zhang L,Luo X,Liao Y,Yang B

Fri Apr 22 00:00:00 UTC 2022

GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the m⁶A Reader YTHDF1.

Cancers

Ning Z,Wu Z,Zhang F,Yang M,Lu Z,Yu B,Long F,Guo Y,Yang K,Hu G,Zhang Y,Li X,Li L,Lin C

Thu Dec 08 00:00:00 UTC 2022

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Journal of hazardous materials

Qi Z,Wang S,Li J,Wen Y,Cui R,Zhang K,Liu Y,Yang X,Zhang L,Xu B,Liu W,Xu Z,Deng Y

Tue Mar 15 00:00:00 UTC 2022

m⁶A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.

Cell reports

Wang L,Zhan G,Maimaitiyiming Y,Su Y,Lin S,Liu J,Su K,Lin J,Shen S,He W,Wang F,Chen J,Sun S,Xue Y,Gu J,Chen X,Zhang J,Zhang L,Wang Q,Chang KJ,Chiou SH,Björklund M,Naranmandura H,Cheng X,Hsu CH

Tue Oct 25 00:00:00 UTC 2022

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.

Clinical & experimental metastasis

Zhao F,Ge F,Xie M,Li Z,Zang C,Kong L,Pu Y,Zheng X,Tan Y

Mon Aug 01 00:00:00 UTC 2022

METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.

Cellular signalling

Cai Y,Yu R,Kong Y,Feng Z,Xu Q

Sun May 01 00:00:00 UTC 2022

RNA m⁶A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.

Molecular therapy : the journal of the American Society of Gene Therapy

Li J,Xie G,Tian Y,Li W,Wu Y,Chen F,Lin Y,Lin X,Wing-Ngor Au S,Cao J,He W,Wang H

Wed Apr 06 00:00:00 UTC 2022

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Peng Z,Gong Y,Wang X,He W,Wu L,Zhang L,Xiong L,Huang Y,Su L,Shi P,Cao X,Liu R,Li Y,Xiao H

Wed Feb 02 00:00:00 UTC 2022

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Peng Z,Gong Y,Wang X,He W,Wu L,Zhang L,Xiong L,Huang Y,Su L,Shi P,Cao X,Liu R,Li Y,Xiao H

Wed Feb 02 00:00:00 UTC 2022

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m⁶A modification.

Cancer cell international

Xu Y,Lv D,Yan C,Su H,Zhang X,Shi Y,Ying K

Fri Jan 07 00:00:00 UTC 2022

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m⁶A modification.

Cancer cell international

Xu Y,Lv D,Yan C,Su H,Zhang X,Shi Y,Ying K

Fri Jan 07 00:00:00 UTC 2022

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m⁶A modification.

Cancer cell international

Xu Y,Lv D,Yan C,Su H,Zhang X,Shi Y,Ying K

Fri Jan 07 00:00:00 UTC 2022

TBK1-METTL3 axis facilitates antiviral immunity.

Cell reports

Chen J,Wei X,Wang X,Liu T,Zhao Y,Chen L,Luo Y,Du H,Li Y,Liu T,Cao L,Zhou Z,Zhang Z,Liang L,Li L,Yan X,Zhang X,Deng X,Yang G,Yin P,Hao J,Yin Z,You F

Tue Feb 15 00:00:00 UTC 2022

Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H₂O₂-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.

International journal of molecular sciences

Wu F,Zhang L,Lai C,Peng X,Yu S,Zhou C,Zhang B,Zhang W

Wed Aug 17 00:00:00 UTC 2022

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

The Journal of biological chemistry

Suphakhong K,Terashima M,Wanna-Udom S,Takatsuka R,Ishimura A,Takino T,Suzuki T

Tue Nov 01 00:00:00 UTC 2022

YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.

Retrovirology

N'Da Konan S,Ségéral E,Bejjani F,Bendoumou M,Ait Said M,Gallois-Montbrun S,Emiliani S

Mon Jan 31 00:00:00 UTC 2022

m⁶A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.

Cell reports

Huang J,Jiang B,Li GW,Zheng D,Li M,Xie X,Pan Y,Wei M,Liu X,Jiang X,Zhang X,Yang L,Bao L,Wang B

Tue Nov 22 00:00:00 UTC 2022

m⁶A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.

Cell reports

Huang J,Jiang B,Li GW,Zheng D,Li M,Xie X,Pan Y,Wei M,Liu X,Jiang X,Zhang X,Yang L,Bao L,Wang B

Tue Nov 22 00:00:00 UTC 2022

N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.

International journal of biological sciences

Hu Z,Li Y,Yuan W,Jin L,Leung WK,Zhang C,Yang Y

Fri Oct 21 00:00:00 UTC 2022

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Journal of clinical laboratory analysis

Li Z,Xu Q,Huangfu N,Chen X,Zhu J

Sat Jan 01 00:00:00 UTC 2022

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Cell death & disease

Zhu Y,Peng X,Zhou Q,Tan L,Zhang C,Lin S,Long M

Mon Apr 18 00:00:00 UTC 2022

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

eLife

Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ

Fri Feb 18 00:00:00 UTC 2022

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

eLife

Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ

Fri Feb 18 00:00:00 UTC 2022

m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.

Cell & bioscience

Duan X,Yang L,Wang L,Liu Q,Zhang K,Liu S,Liu C,Gao Q,Li L,Qin G,Zhang Y

Sat May 14 00:00:00 UTC 2022

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.

Cell & bioscience

Chen H,Yu Y,Yang M,Huang H,Ma S,Hu J,Xi Z,Guo H,Yao G,Yang L,Huang X,Zhang F,Tan G,Wu H,Zheng W,Li L

Wed Feb 23 00:00:00 UTC 2022

Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.

Cancer science

Liu T,Wang H,Fu Z,Wang Z,Wang J,Gan X,Wang A,Wang L

Tue Feb 01 00:00:00 UTC 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 UTC 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 UTC 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 UTC 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 UTC 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 UTC 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 UTC 2022

YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.

Archives of biochemistry and biophysics

He M,Li D,Fang C,Xu Q

Thu Dec 15 00:00:00 UTC 2022

The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.

Evidence-based complementary and alternative medicine : eCAM

Huang Q,Li CY,Zhang N,Zhang Q,Li HY,Shen Y,Xie LS,Yu SG,Wu QF

Fri Apr 01 00:00:00 UTC 2022

The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.

Evidence-based complementary and alternative medicine : eCAM

Huang Q,Li CY,Zhang N,Zhang Q,Li HY,Shen Y,Xie LS,Yu SG,Wu QF

Fri Apr 01 00:00:00 UTC 2022

Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.

Nutrients

Xu Z,Qin Y,Lv B,Tian Z,Zhang B

Fri Jan 07 00:00:00 UTC 2022

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Chen W,Wang Z,Wang S,Zan J,Zheng L,Zhao W

Thu Dec 01 00:00:00 UTC 2022

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Chen W,Wang Z,Wang S,Zan J,Zheng L,Zhao W

Thu Dec 01 00:00:00 UTC 2022

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

EBioMedicine

Li HB,Huang G,Tu J,Lv DM,Jin QL,Chen JK,Zou YT,Lee DF,Shen JN,Xie XB

Mon Aug 01 00:00:00 UTC 2022

Lactylation-driven METTL3-mediated RNA m⁶A modification promotes immunosuppression of tumor-infiltrating myeloid cells.

Molecular cell

Xiong J,He J,Zhu J,Pan J,Liao W,Ye H,Wang H,Song Y,Du Y,Cui B,Xue M,Zheng W,Kong X,Jiang K,Ding K,Lai L,Wang Q

Thu May 05 00:00:00 UTC 2022

Fusobacterium nucleatum reduces METTL3-mediated m⁶A modification and contributes to colorectal cancer metastasis.

Nature communications

Chen S,Zhang L,Li M,Zhang Y,Sun M,Wang L,Lin J,Cui Y,Chen Q,Jin C,Li X,Wang B,Chen H,Zhou T,Wang L,Hsu CH,Zhuo W

Thu Mar 10 00:00:00 UTC 2022

UPF1 promotes rapid degradation of m⁶A-containing RNAs.

Cell reports

Boo SH,Ha H,Lee Y,Shin MK,Lee S,Kim YK

Tue May 24 00:00:00 UTC 2022

Involvement of YTHDF1 in renal fibrosis progression via up-regulating YAP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xing J,He YC,Wang KY,Wan PZ,Zhai XY

Tue Feb 01 00:00:00 UTC 2022

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Cell death & disease

Yao X,Li W,Li L,Li M,Zhao Y,Fang D,Zeng X,Luo Z

Wed Mar 23 00:00:00 UTC 2022

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Cell death & disease

Yao X,Li W,Li L,Li M,Zhao Y,Fang D,Zeng X,Luo Z

Wed Mar 23 00:00:00 UTC 2022

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Cell death & disease

Yao X,Li W,Li L,Li M,Zhao Y,Fang D,Zeng X,Luo Z

Wed Mar 23 00:00:00 UTC 2022

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N ⁶-Methyladenosine-Modified RNAs.

ACS pharmacology & translational science

Micaelli M,Dalle Vedove A,Cerofolini L,Vigna J,Sighel D,Zaccara S,Bonomo I,Poulentzas G,Rosatti EF,Cazzanelli G,Alunno L,Belli R,Peroni D,Dassi E,Murakami S,Jaffrey SR,Fragai M,Mancini I,Lolli G,Quattrone A,Provenzani A

Fri Oct 14 00:00:00 UTC 2022

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Brain research

Li M,Zhong X,Zhao Z,Zeng Z,Yuan Q,Xiao X,Zu X,Liu J

Tue Feb 15 00:00:00 UTC 2022

Novel insight of N⁶-methyladenosine modified subtypes in abdominal aortic aneurysm.

Frontiers in genetics

Wang K,Kan Q,Ye Y,Qiu J,Huang L,Wu R,Yao C

Sat Dec 10 00:00:00 UTC 2022

Novel insight of N⁶-methyladenosine modified subtypes in abdominal aortic aneurysm.

Frontiers in genetics

Wang K,Kan Q,Ye Y,Qiu J,Huang L,Wu R,Yao C

Sat Dec 10 00:00:00 UTC 2022

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N⁶-Methyladenosine-Modified Yap Expression.

Research (Washington, D.C.)

Wang L,Yu P,Wang J,Xu G,Wang T,Feng J,Bei Y,Xu J,Wang H,Das S,Xiao J

Sat Jul 16 00:00:00 UTC 2022

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N⁶-Methyladenosine-Modified Yap Expression.

Research (Washington, D.C.)

Wang L,Yu P,Wang J,Xu G,Wang T,Feng J,Bei Y,Xu J,Wang H,Das S,Xiao J

Sat Jul 16 00:00:00 UTC 2022

YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

Journal of gastroenterology and hepatology

Huang X,Zhu L,Wang L,Huang W,Tan L,Liu H,Huo J,Su T,Zhang M,Kuang M,Li X,Dai Z,Xu L

Wed Jun 01 00:00:00 UTC 2022

YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

Journal of gastroenterology and hepatology

Huang X,Zhu L,Wang L,Huang W,Tan L,Liu H,Huo J,Su T,Zhang M,Kuang M,Li X,Dai Z,Xu L

Wed Jun 01 00:00:00 UTC 2022

YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

Journal of gastroenterology and hepatology

Huang X,Zhu L,Wang L,Huang W,Tan L,Liu H,Huo J,Su T,Zhang M,Kuang M,Li X,Dai Z,Xu L

Wed Jun 01 00:00:00 UTC 2022

The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

The Journal of experimental medicine

Ma S,Yan J,Barr T,Zhang J,Chen Z,Wang LS,Sun JC,Chen J,Caligiuri MA,Yu J

Mon Aug 02 00:00:00 UTC 2021

Comparison of RNA m⁶A and DNA methylation profiles between mouse female germline stem cells and STO cells.

Molecular therapy. Nucleic acids

Zhao X,Tian GG,Fang Q,Pei X,Wang Z,Wu J

Fri Mar 05 00:00:00 UTC 2021

N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay.

EMBO reports

Xia TL,Li X,Wang X,Zhu YJ,Zhang H,Cheng W,Chen ML,Ye Y,Li Y,Zhang A,Dai DL,Zhu QY,Yuan L,Zheng J,Huang H,Chen SQ,Xiao ZW,Wang HB,Roy G,Zhong Q,Lin D,Zeng YX,Wang J,Zhao B,Gewurz BE,Chen J,Zuo Z,Zeng MS

Wed Apr 07 00:00:00 UTC 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 UTC 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 UTC 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 UTC 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 UTC 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 UTC 2021

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N⁶-methyladenosine-dependent YTHDF binding.

Nature communications

Wang W,Shao F,Yang X,Wang J,Zhu R,Yang Y,Zhao G,Guo D,Sun Y,Wang J,Xue Q,Gao S,Gao Y,He J,Lu Z

Mon Jun 21 00:00:00 UTC 2021

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N⁶-methyladenosine-dependent YTHDF binding.

Nature communications

Wang W,Shao F,Yang X,Wang J,Zhu R,Yang Y,Zhao G,Guo D,Sun Y,Wang J,Xue Q,Gao S,Gao Y,He J,Lu Z

Mon Jun 21 00:00:00 UTC 2021

GR-mediated transcriptional regulation of m⁶A metabolic genes contributes to diet-induced fatty liver in hens.

Journal of animal science and biotechnology

Feng Y,Li Y,Jiang W,Hu Y,Jia Y,Zhao R

Tue Dec 07 00:00:00 UTC 2021

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.

Signal transduction and targeted therapy

Li Q,Ni Y,Zhang L,Jiang R,Xu J,Yang H,Hu Y,Qiu J,Pu L,Tang J,Wang X

Tue Feb 23 00:00:00 UTC 2021

YTHDF1 Aggravates the Progression of Cervical Cancer Through m⁶A-Mediated Up-Regulation of RANBP2.

Frontiers in oncology

Wang H,Luo Q,Kang J,Wei Q,Yang Y,Yang D,Liu X,Liu T,Yi P

Tue Apr 06 00:00:00 UTC 2021

YTHDF1 Aggravates the Progression of Cervical Cancer Through m⁶A-Mediated Up-Regulation of RANBP2.

Frontiers in oncology

Wang H,Luo Q,Kang J,Wei Q,Yang Y,Yang D,Liu X,Liu T,Yi P

Tue Apr 06 00:00:00 UTC 2021

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

Oncoimmunology

Tsuchiya K,Yoshimura K,Inoue Y,Iwashita Y,Yamada H,Kawase A,Watanabe T,Tanahashi M,Ogawa H,Funai K,Shinmura K,Suda T,Sugimura H

Fri Oct 15 00:00:00 UTC 2021

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

Oncoimmunology

Tsuchiya K,Yoshimura K,Inoue Y,Iwashita Y,Yamada H,Kawase A,Watanabe T,Tanahashi M,Ogawa H,Funai K,Shinmura K,Suda T,Sugimura H

Fri Oct 15 00:00:00 UTC 2021

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.

Nucleic acids research

Xia Z,Tang M,Ma J,Zhang H,Gimple RC,Prager BC,Tang H,Sun C,Liu F,Lin P,Mei Y,Du R,Rich JN,Xie Q

Wed Jul 21 00:00:00 UTC 2021

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.

Nucleic acids research

Xia Z,Tang M,Ma J,Zhang H,Gimple RC,Prager BC,Tang H,Sun C,Liu F,Lin P,Mei Y,Du R,Rich JN,Xie Q

Wed Jul 21 00:00:00 UTC 2021

METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.

Aging

He B,Wang J

Tue Oct 05 00:00:00 UTC 2021

Reprogramming of m⁶A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.

RNA biology

Wang YJ,Yang B,Lai Q,Shi JF,Peng JY,Zhang Y,Hu KS,Li YQ,Peng JW,Yang ZZ,Li YT,Pan Y,Koeffler HP,Liao JY,Yin D

Fri Jan 01 00:00:00 UTC 2021

The m⁶A "reader" YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839.

Cell death & disease