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Abnova
ZA20D1 Monoclonal Antibody (2B4)
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Product Details
H00056957-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
2B4
Immunogen
ZA20D1 (NP_064590, 759 a.a. approximately 858 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DSIPSLEPGS HSKDGLHRGA LLPPPYRVAD SYSNGYREPP EPDGWAGGLR GLPPTQTKCK QPNCSFYGHP ETNNFCSCCY REELRRRERE PDGELLVHRF
Target Information
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cellular zinc finger anti-NF-kappa-B protein; cellular zinc finger anti-NF-kappaB Cezanne; Cezanne; OTU domain containing 7B; OTU domain-containing protein 7B; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne; zinc finger, A20 domain containing 1
Gene Aliases: CEZANNE; OTUD7B; ZA20D1
UniProt ID: (Human) Q6GQQ9
Entrez Gene ID: (Human) 56957
negative regulation of transcription from RNA polymerase II promoter
mucosal immune response
immune response
negative regulation of interleukin-8 production
protein K11-linked deubiquitination
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein K63-linked deubiquitination
protein K48-linked deubiquitination
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of protein localization to nucleus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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