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Proteintech
ZAP70 Monoclonal Antibody (1A11G9)
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Product Details
60200-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1A11G9
Immunogen
ZAP70 Fusion Protein Ag7943 (149-493 aa encoded by BC039039)
Conjugate
Form
Liquid
Concentration
1.37 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: STLTHPQRR IDTLNSDGYT PEPARITSPD KPRPMPMDTS VYESPYSDPE ELKDKKLFLK RDNLLIADIE LGCGNFGSVR QGVYRMRKKQ IDVAIKVLKQ GTEKADTEEM MREAQIMHQL DNPYIVRLIG VCQAEALMLV MEMAGGGPLH KFLVGKREEI PVSNVAELLH QVSMGMKYLE EKNFVHRDLA ARNVLLVNRH YAKISDFGLS KALGADDSYY TARSAGKWPL KWYAPECINF RKFSSRSDVW SYGVTMWEAL SYGQKPYKKM KGPEVMAFIE QGKRMECPPE CPPELYALMS DCWIYKWEDR PDFLTVEQRM RACYYSLASK VEGPPGSTQK AEAACA (149-493 aa encoded by BC039039)
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; EC 2.7.10.2; FLJ17670; FLJ17679; kinase ZAP70; Selective T cell defect; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; ZA70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Aliases: ADMIO2; IMD48; mrtle; mur; SRK; STCD; STD; TZK; ZAP-70; ZAP70
UniProt ID: (Human) P43403, (Mouse) P43404
Entrez Gene ID: (Human) 7535, (Mouse) 22637
phosphotyrosine binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
adaptive immune response
macrophage activation involved in immune response
neutrophil activation involved in immune response
protein phosphorylation
inflammatory response
immune response
transmembrane receptor protein tyrosine kinase signaling pathway
peptidyl-tyrosine phosphorylation
T cell differentiation
positive regulation of cell adhesion mediated by integrin
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
T cell activation
B cell activation
positive regulation of mast cell degranulation
beta selection
positive thymic T cell selection
negative thymic T cell selection
innate immune response
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
B cell receptor signaling pathway
T cell aggregation
T cell migration
regulation of platelet aggregation
immune system process
phosphorylation
cell migration
cell differentiation
thymic T cell selection
protein autophosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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