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ZBTB5 Antibody (PA5-78660) in IHC (P)
ZBTB5 Polyclonal Antibody detects ZBTB5 protein at nucleus and cytosol on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. ZBTB5 Polyclonal Antibody (Product # PA5-78660) dilution: 1:1,000. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-78660
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ZBTB5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.87 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736814
Product Specific Information
Predicted Reactivity: Human (100%), Xenopus laevis (81%), Rhesus Monkey (99%), Bovine (96%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: expressed in brain and neural tube; RP11-397D12.5; Transcription factor ZNF-POZ; Zinc finger and BTB domain-containing protein 5
Gene Aliases: 5930421I10; 9430083K24Rik; AI646847; KIAA0354; mKIAA0354; ZBTB5
UniProt ID: (Human) O15062, (Mouse) Q7TQG0
Entrez Gene ID: (Human) 9925, (Mouse) 230119, (Rat) 298084
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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