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Product Details
PA5-101961
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZC3H13(Accession Q5T200), corresponding to amino acid residues R1577-N1627.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2851393
Product Specific Information
Antibody detects endogenous levels of total ZC3H13.
Target Information
The zinc finger CCCH domain-containing protein 13 (ZC3H13) is a 1668 amino acid protein that contains one C3H1-type zinc finger. ZC3H13 is phosphorylated upon DNA damage, most likely by ATM or ATR. Two isoforms of ZC3H13 exists as a result of alternative splicing events. The gene encoding ZC3H13 maps to chromosome 13, which contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zinc finger CCCH domain-containing protein 13
Gene Aliases: 2600010B19Rik; 3110050K21Rik; 4930570G11Rik; C87618; KIAA0853; ZC3H13
UniProt ID: (Human) Q5T200, (Mouse) E9Q784
Entrez Gene ID: (Human) 23091, (Mouse) 67302
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