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Immunogen sequence: GQLQPSRPTR ARGTCSVEDP LLVCQKEPGK PRMVKSVGSV GDSPREPRRT VSESVIAVKA SFPSSALPPR TGVALGRKLG SHSVASCAPQ LLGDRRVGAG H
Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 66%.
Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Smad-interacting CPSF-like factor; Zinc finger CCCH domain-containing protein 3; zinc finger CCCH type domain containing 3; zinc finger CCCH-type domain containing 3
Gene Aliases: KIAA0150; SMICL; ZC3H3; ZC3HDC3
UniProt ID: (Human) Q8IXZ2
Entrez Gene ID: (Human) 23144
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