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Invitrogen
ZC3H8 Polyclonal Antibody
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Product Details
PA5-101962
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZC3H8(Accession Q8N5P1), corresponding to amino acid residues D88-N138.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2851394
Product Specific Information
Antibody detects endogenous levels of total ZC3H8.
Target Information
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fetal liver zinc finger 1; fetal liver zinc finger 1; putative zinc finger protein FLIZ1; Fetal liver zinc finger protein 1; Zinc finger CCCH domain-containing protein 8; zinc finger CCCH type domain containing 8; zinc finger CCCH-type domain containing 8
Gene Aliases: AU020882; E130108N08Rik; Fliz1; ZC3H8; ZC3HDC8
UniProt ID: (Human) Q8N5P1, (Mouse) Q9JJ48
Entrez Gene ID: (Human) 84524, (Mouse) 57432
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
poly(A) RNA binding
metal ion binding
RNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
negative regulation of T cell differentiation in thymus
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
T cell homeostasis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase III promoter
response to antibiotic
positive regulation of thymocyte apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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