Proteintech

ZDHHC5 Polyclonal Antibody

ZDHHC5 Antibody in Immunocytochemistry (ICC/IF)

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ZDHHC5 Antibody (21324-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using ZDHHC5 antibody 21324-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

ZDHHC5 Antibody in Flow Cytometry (Flow)

ZDHHC5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21324-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ZDHHC5 Fusion Protein Ag14891 (366-715 aa encoded by BC026967)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AMPHSSSAK LSRGDSLKEP TSIAESSRHP SYRSEPSLEP ESFRSPTFGK SFHFDPLSSG SRSSSLKSAQ GTGFELGQLQ SIRSEGTTST SYKSLANQTR NGSLSYDSLL TPSDSPDFES VQAGPEPDPP LGYTSPFLSA RLAQQREAER HPRLVPTGPT HREPSPVRYD NLSRHIVASL QEREKLLRQS PPLPGREEEP GLGDSGIQST PGSGHAPRTS SSSDDSKRSP LGKTPLGRPA VPRFGKPDGL RGRGVGSPEP GPTAPYLGRS MSYSSQKAQP GVSETEEVAL QPLLTPKDEV QLKTTYSKSN GQPKSLGSAS PGPGQPPLSS PTRGGVKKVS GVGGTTYEIS V (366-715 aa encoded by BC026967)

Target Information

Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models.

Cell death discovery

Wang Y,Zhang S,He H,Luo H,Xia Y,Jiang Y,Jiang J,Sun L

Sat Feb 11 00:00:00 UTC 2023

Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models.

Cell death discovery

Wang Y,Zhang S,He H,Luo H,Xia Y,Jiang Y,Jiang J,Sun L

Sat Feb 11 00:00:00 UTC 2023

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation.

bioRxiv : the preprint server for biology

Du G,Healy LB,David L,Walker C,Fontana P,Dong Y,Devant P,Puthenveetil R,Ficarro SB,Banerjee A,Kagan JC,Lieberman J,Wu H

Tue Mar 07 00:00:00 UTC 2023

Docosahexaenoic acid reverses PD-L1-mediated immune suppression by accelerating its ubiquitin-proteasome degradation.

The Journal of nutritional biochemistry

Zhang H,Chen H,Yin S,Fan L,Jin C,Zhao C,Hu H

Wed Feb 01 00:00:00 UTC 2023

ZDHHC2-Mediated AGK Palmitoylation Activates AKT-mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma.

Cancer research

Sun Y,Zhu L,Liu P,Zhang H,Guo F,Jin X

Thu Jun 15 00:00:00 UTC 2023

Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation.

Cell death and differentiation

Zhou L,He X,Wang L,Wei P,Cai Z,Zhang S,Jin S,Zeng H,Cui J

Mon Aug 01 00:00:00 UTC 2022

Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation.

Cell death and differentiation

Zhou L,He X,Wang L,Wei P,Cai Z,Zhang S,Jin S,Zeng H,Cui J

Mon Aug 01 00:00:00 UTC 2022

AKAP150 and its Palmitoylation Contributed to Pain Hypersensitivity Via Facilitating Synaptic Incorporation of GluA1-Containing AMPA Receptor in Spinal Dorsal Horn.

Molecular neurobiology

Li Y,Bai X,Gao M,Chen H,Ma X,Zhang Y,Bai H,Liu Y,Hu X,Suo Z

Wed Dec 01 00:00:00 UTC 2021

AKAP150 and its Palmitoylation Contributed to Pain Hypersensitivity Via Facilitating Synaptic Incorporation of GluA1-Containing AMPA Receptor in Spinal Dorsal Horn.

Molecular neurobiology

Li Y,Bai X,Gao M,Chen H,Ma X,Zhang Y,Bai H,Liu Y,Hu X,Suo Z

Wed Dec 01 00:00:00 UTC 2021

miR-96-5p enhances cell proliferation and invasion via targeted regulation of ZDHHC5 in gastric cancer.

Bioscience reports

Wang B,Liu X,Meng X

Thu Apr 30 00:00:00 UTC 2020

DHHC5 Mediates β-Adrenergic Signaling in Cardiomyocytes by Targeting Gα Proteins.

Biophysical journal

Chen JJ,Marsden AN,Scott CA,Akimzhanov AM,Boehning D

Tue Feb 25 00:00:00 UTC 2020

MiR-96-5p inhibition induces cell apoptosis in gastric adenocarcinoma.

World journal of gastroenterology

Zhou HY,Wu CQ,Bi EX

Sat Dec 21 00:00:00 UTC 2019

ZDHHC8 critically regulates seizure susceptibility in epilepsy.

Cell death & disease

Yang Q,Zheng F,Hu Y,Yang Y,Li Y,Chen G,Wang W,He M,Zhou R,Ma Y,Xu D,Tian X,Gao X,Wang Q,Wang X

Mon Jul 23 00:00:00 UTC 2018

ZDHHC8 critically regulates seizure susceptibility in epilepsy.

Cell death & disease

Yang Q,Zheng F,Hu Y,Yang Y,Li Y,Chen G,Wang W,He M,Zhou R,Ma Y,Xu D,Tian X,Gao X,Wang Q,Wang X

Mon Jul 23 00:00:00 UTC 2018

DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling.

Scientific reports