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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • ZEB2 Antibodies

          Proteintech

          ZEB2 Polyclonal Antibody

          59 References
          View all (40) ZEB2 antibodies

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          Datasheet
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          Cite ZEB2 Polyclonal Antibody

          • Antibody Testing Data (5)
          ZEB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          ZEB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          ZEB2 Antibody (14026-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 14026-1-AP ( ZEB2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          ZEB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          ZEB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          ZEB2 Antibody in Western Blot (WB)
          ZEB2 Antibody in Western Blot (WB)
          ZEB2 Antibody in Western Blot (WB)

          Product Details

          14026-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:3,000
          View 50 publications 50 publications

          Immunohistochemistry (IHC)

          -
          View 5 publications 5 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          -
          View 3 publications 3 publications

          Not applicable (N/A)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          ZEB2 Fusion Protein Ag5171 (1-128 aa encoded by BC060819)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.38 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: MKQPIMADG PRCKRRKQAN PRRKNVVNYD NVVDTGSETD EEDKLHIAED DGIANPLDQE TSPASVPNHE SSPHVSQALL PREEEEDEIR EGGVEHPWHN NEILQASVDG PGKCLKSLDL FLYHLHIFN (1-128 aa encoded by BC060819 )

          Target Information

          ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b

          View more View less

          Gene Aliases: 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B; ZFX1B; Zfxh1b

          View more View less

          UniProt ID: (Human) O60315, (Mouse) Q9R0G7

          View more View less

          Entrez Gene ID: (Human) 9839, (Mouse) 24136, (Rat) 311071

          View more View less

          Function(s)
          transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding phosphatase regulator activity metal ion binding R-SMAD binding nucleic acid binding molecular_function
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter neural crest cell migration somitogenesis neural tube closure transcription from RNA polymerase II promoter nervous system development corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of JUN kinase activity positive regulation of melanocyte differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of melanin biosynthetic process developmental pigmentation collateral sprouting positive regulation of axonogenesis mammillary axonal complex development melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization transcription, DNA-templated regulation of transcription, DNA-templated central nervous system development embryonic morphogenesis biological_process
          It has to be done as per old AB suggested Products section.
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