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          • Primary Antibodies ›
          • ZFPM1 Antibodies

          Invitrogen

          ZFPM1 Polyclonal Antibody

          View all (12) ZFPM1 antibodies
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          Datasheet
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          Cite ZFPM1 Polyclonal Antibody

          Product Details

          PA5-68795

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.2-1.0 µg/mL
          -
          Product Specifications

          Species Reactivity

          Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          synthetic peptide directed towards the N terminal region of mouse ZFPM1
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS with 2% sucrose

          Contains

          0.09% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2689301

          Product Specific Information

          This target displays homology in the following species: Mouse: 100%; Rat: 85%

          Target Information

          ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: FOG-1; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA-1; Zinc finger protein multitype 1; Zinc finger protein ZFPM1

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          Gene Aliases: FOG; Fog1; Zfpm1

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          UniProt ID: (Mouse) O35615

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          Entrez Gene ID: (Mouse) 22761

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          Function(s)
          transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding nucleic acid binding DNA binding transcription corepressor activity protein binding transcription factor binding metal ion binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis atrioventricular valve morphogenesis mitral valve formation tricuspid valve formation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter heart development regulation of definitive erythrocyte differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation granulocyte differentiation negative regulation of protein binding regulation of chemokine production embryonic hemopoiesis megakaryocyte development positive regulation of interferon-gamma biosynthetic process negative regulation of interleukin-4 biosynthetic process negative regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter homeostasis of number of cells cardiac muscle tissue morphogenesis definitive erythrocyte differentiation primitive erythrocyte differentiation negative regulation of mast cell differentiation ventricular septum morphogenesis atrial septum morphogenesis transcriptional activation by promoter-enhancer looping
          It has to be done as per old AB suggested Products section.
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