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Invitrogen
ZFYVE19 Monoclonal Antibody (3G4-2B11)
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Product Details
MA5-22803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
3G4-2B11
Immunogen
ZFYVE19 (AAH15738.1, 1 a.a. ~ 396 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606037
Product Specific Information
Peptide Sequence: MESRCYGCAV KFTLFKKEYG CKNCGRAFCS GCLSFSAAVP RTGNTQQKVC KQCHEVLTRG SSANASKWSP PQNYKKRVAA LEAKQKPSTS QSQGLTRQDQ MIAERLARLR QENKPKLVPS QAEIEARLAA LKDERQGSIP STQEMEARLA ALQGRVLPSQ TPQPAHHTPD TRTQAQQTQD LLTQLAAEVA IDESWKGGGP AASLQNDLNQ GGPGSTNSKR QANWSLEEEK SRLLAEAALE LREENTRQER ILALAKRLAM LRGQDPERVT LQDYRLPDSD DDEDEETAIQ RVLQQLTEEA ALDEASGFNI PAEQASRPWT QPRGAEPEAQ DVDPRPEAEE EELPWCCICN EDATLRCAGC DGDLFCARCF REGHDAFELK EHQTSAYSPP RAGQEH
Target Information
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abscission/NoCut checkpoint regulator; ANCHR; MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19; zinc finger, FYVE domain containing 19
Gene Aliases: ANCHR; MPFYVE; ZFYVE19
UniProt ID: (Human) Q96K21
Entrez Gene ID: (Human) 84936
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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