Proteintech

ZFYVE27 Polyclonal Antibody

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ZFYVE27 Antibody (12680-1-AP) in WB

Mouse testis tissue were subjected to SDS PAGE followed by western blot with 12680-1-AP (ZFYVE27 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

ZFYVE27 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12680-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ZFYVE27 Fusion Protein Ag3369 (217-411 aa encoded by BC030621)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VEFFRVVSE YRASLQQRMN PKQEEHAFES PPPPDVGGKD GLMDSTPALT PTEDLTPGSV EEAEEAEPDE EFKDAIEETH LVVLEDDEGA PCPAEDELAL QDNGFLSKNE VLRSKVSRLT ERLRKRYPTN NFGNCTGCSA TFSVLKKRRS CSNCGNSFCS RCCSFKVPKS SMGATAPEAQ RETVFVCASC NQTLSK (217-411 aa encoded by BC030621)

Target Information

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model.

Communications biology

Mathur P,De Barros Santos C,Lachuer H,Patat J,Latgé B,Radvanyi F,Goud B,Schauer K

Sat Jan 28 00:00:00 UTC 2023

Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model.

Communications biology

Mathur P,De Barros Santos C,Lachuer H,Patat J,Latgé B,Radvanyi F,Goud B,Schauer K

Sat Jan 28 00:00:00 UTC 2023

ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology.

Nature methods

Lu M,Christensen CN,Weber JM,Konno T,Läubli NF,Scherer KM,Avezov E,Lio P,Lapkin AA,Kaminski Schierle GS,Kaminski CF

Sat Apr 01 00:00:00 UTC 2023

Protrudin regulates FAK activation, endothelial cell migration and angiogenesis.

Cellular and molecular life sciences : CMLS

Arora A,Kivelä AM,Wang L,Minkeviciene R,Taskinen JH,Zhang B,Koponen A,Sun J,Shirane M,Zhou Y,Hotulainen P,Raiborg C,Olkkonen VM

Mon Apr 04 00:00:00 UTC 2022

A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.

Cell reports

Brachet A,Lario A,Fernández-Rodrigo A,Heisler FF,Gutiérrez Y,Lobo C,Kneussel M,Esteban JA

Tue Aug 03 00:00:00 UTC 2021

A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.

Cell reports

Brachet A,Lario A,Fernández-Rodrigo A,Heisler FF,Gutiérrez Y,Lobo C,Kneussel M,Esteban JA

Tue Aug 03 00:00:00 UTC 2021

PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria.

Nature communications

Elbaz-Alon Y,Guo Y,Segev N,Harel M,Quinnell DE,Geiger T,Avinoam O,Li D,Nunnari J

Mon Jul 20 00:00:00 UTC 2020

PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria.

Nature communications

Elbaz-Alon Y,Guo Y,Segev N,Harel M,Quinnell DE,Geiger T,Avinoam O,Li D,Nunnari J

Mon Jul 20 00:00:00 UTC 2020

Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry.

Nature communications

Bagchi P,Torres M,Qi L,Tsai B

Fri Feb 28 00:00:00 UTC 2020

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.

Nature communications

Petrova V,Pearson CS,Ching J,Tribble JR,Solano AG,Yang Y,Love FM,Watt RJ,Osborne A,Reid E,Williams PA,Martin KR,Geller HM,Eva R,Fawcett JW

Thu Nov 05 00:00:00 UTC 2020

ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic.

Cellular and molecular life sciences : CMLS

Connell JW,Allison RJ,Rodger CE,Pearson G,Zlamalova E,Reid E

Wed Jul 01 00:00:00 UTC 2020

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions.

Scientific reports

Zhang C,Lu J,Su H,Yang J,Zhou D

Fri Apr 21 00:00:00 UTC 2017

Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions.

Scientific reports

Zhang C,Lu J,Su H,Yang J,Zhou D

Fri Apr 21 00:00:00 UTC 2017

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia.

The Journal of biological chemistry

Hashimoto Y,Shirane M,Matsuzaki F,Saita S,Ohnishi T,Nakayama KI

Fri May 09 00:00:00 UTC 2014

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia.

The Journal of biological chemistry

Hashimoto Y,Shirane M,Matsuzaki F,Saita S,Ohnishi T,Nakayama KI

Fri May 09 00:00:00 UTC 2014

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.