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Invitrogen
ZIC Pan Polyclonal Antibody
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ZIC Pan Antibody (PA5-103289) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded ZIC Pan in human liver tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with ZIC Pan polyclonal antibody (Product # PA5-103289) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-103289
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZIC1(Accession Q15915), corresponding to amino acid residues G328-R378.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852641
Product Specific Information
Antibody detects endogenous levels of total ZIC1/2/3/4/5.
Target Information
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GENA 29; heterotaxy 1; kumba; Odd paired-related protein; odd-paired homolog; odd-paired related; Opa-related protein; Zic family member 1 (odd-paired homolog, Drosophila); Zic family member 2 (odd-paired homolog, Drosophila); Zic family member 3 (odd-paired homolog, Drosophila); Zic family member 4 (odd-paired homolog, Drosophila); Zic family member 5 (odd-paired homolog, Drosophila); zic protein member 1; zinc family member 4 protein HZIC4; zinc family member 5 protein; Zinc finger protein 201; Zinc finger protein 203; Zinc finger protein of the cerebellum 1; Zinc finger protein of the cerebellum 2; Zinc finger protein of the cerebellum 3; Zinc finger protein of the cerebellum 4; Zinc finger protein of the cerebellum 5; Zinc finger protein ZIC 1; Zinc finger protein ZIC 2; Zinc finger protein ZIC 3; Zinc finger protein ZIC 4; Zinc finger protein ZIC 5
Gene Aliases: 1700049L20Rik; Bn; CRS6; HPE5; HTX; HTX1; Ka; Ku; Opr; RGD1561261; VACTERLX; ZIC; ZIC1; ZIC2; ZIC3; ZIC4; ZIC5; ZNF201; ZNF203
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
metal ion binding
DNA binding
chromatin DNA binding
protein binding
sequence-specific DNA binding
molecular_function
nucleic acid binding
transcription from RNA polymerase II promoter
pattern specification process
central nervous system development
brain development
adult walking behavior
biological_process
regulation of smoothened signaling pathway
spinal cord development
positive regulation of protein import into nucleus
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neural tube closure
regulation of transcription, DNA-templated
cell differentiation
forebrain development
nervous system development
visual perception
retinal ganglion cell axon guidance
cilium organization
negative regulation of transcription, DNA-templated
developmental pigmentation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
heart looping
determination of left/right symmetry
anterior/posterior pattern specification
lung development
somatic stem cell population maintenance
determination of pancreatic left/right asymmetry
determination of left/right asymmetry in nervous system
determination of digestive tract left/right asymmetry
determination of liver left/right asymmetry
inner ear morphogenesis
transcription, DNA-templated
multicellular organism development
skeletal system development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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