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Invitrogen
ZIC1 Monoclonal Antibody (1A8)
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Product Details
MA5-20238
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1A8
Immunogen
ZIC1 (NP_003403, 139 a.a. ~ 212 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607721
Product Specific Information
Peptide Sequence: GHLLFPGLHE QAAGHASPNV VNGQMRLGFS GDMYPRPEQY GQVTSPRSEH YAAPQLHGYG PMNVNMAAHH GAGA
Target Information
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Zic family member 1 (odd-paired homolog, Drosophila); zic protein member 1; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; Zinc finger protein ZIC 1
Gene Aliases: CRS6; ZIC; ZIC1; ZNF201
UniProt ID: (Human) Q15915
Entrez Gene ID: (Human) 7545, (Rat) 64618
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
metal ion binding
molecular_function
nucleic acid binding
transcription from RNA polymerase II promoter
pattern specification process
central nervous system development
brain development
adult walking behavior
biological_process
regulation of smoothened signaling pathway
spinal cord development
positive regulation of protein import into nucleus
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell differentiation
inner ear morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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