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FIGURE: 1 / 6
ZIP12 Antibody (PA5-85934) in ICC/IF
Immunocytochemical analysis of ZIP12 in SH-SY5Y cells using a ZIP12 Polyclonal antibody (Product # PA5-85934) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Product Details
PA5-85934
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human zip12 aa 685-691 (extracellular).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2802735
Target Information
The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIV-1 subfamily of ZIP zinc transporter 8; LZT-Hs8; solute carrier family 39 (metal ion transporter), member 12; solute carrier family 39 (zinc transporter), member 12; Solute carrier family 39 member 12; Zinc transporter ZIP12; ZIP-12; Zrt- and Irt-like protein 12
Gene Aliases: AW046938; bA570F3.1; Gm731; LZT-Hs8; SLC39A12; ZIP-12; ZIP12
UniProt ID: (Human) Q504Y0, (Mouse) Q5FWH7
Entrez Gene ID: (Human) 221074, (Mouse) 277468, (Rat) 291328
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