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ZIP14 Antibody (PA5-87880) in IHC (P)
Immunohistochemistry analysis of ZIP14 in paraffin-embedded human liver cancer. Samples were incubated with ZIP14 Polyclonal antibody (Product # PA5-87880) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-87880
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human ZIP14 (NP_0011219031)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2804476
Product Specific Information
Positive Samples: LO2, HeLa; Cellular Location: Cell membrane, Cell projection, Multi-pass membrane protein, lamellipodium
Immunogen sequence: EENEQTEEGR PSAVE
Target Information
The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Factor for adipocyte differentiation 123; FAD-123; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Metal cation symporter ZIP14; solute carrier family 39 (metal ion transporter), member 14; solute carrier family 39 (zinc transporter), member 14; Solute carrier family 39 member 14; zinc transporter ZIP14; ZIP-14; Zrt- and Cig19; Zrt- and Irt-like protein 14; Zrt-, Irt-like protein 14
Gene Aliases: cig19; FAD-123; Fad123; HMNDYT2; KIAA0062; LZT-Hs4; NET34; SLC39A14; ZIP-14; ZIP14
UniProt ID: (Human) Q15043, (Mouse) Q75N73
Entrez Gene ID: (Human) 23516, (Rat) 306009, (Mouse) 213053
cellular zinc ion homeostasis
zinc II ion transmembrane transport
zinc II ion transmembrane import
ferrous iron transmembrane transport
iron ion transport
zinc II ion transport
ferrous iron transport
iron ion transmembrane transport
transport
ion transport
metal ion transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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