Proteintech

ZIP4 Polyclonal Antibody

ZIP4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ZIP4 Antibody (20625-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 20625-1-AP ( ZIP4 antibody at dilution of 1:200 (under 40x lens).

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Product Details

20625-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ZIP4 Fusion Protein Ag14524 (23-327 aa encoded by BC062625)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.51 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SPPAGLLSL LTSGQGALDQ EALGGLLNTL ADRVHCTNGP CGKCLSVEDA LGLGEPEGSG LPPGPVLEAR YVARLSAAAV LYLSNPEGTC EDTRAGLWAS HADHLLALLE SPKALTPGLS WLLQRMQARA AGQTPKTACV DIPQLLEEAV GAGAPGSAGG VLAALLDHVR SGSCFHALPS PQYFVDFVFQ QHSSEVPMTL AELSALMQRL GVGREAHSDH SHRHRGASSR DPVPLISSSN SSSVWDTVCL SARDVMAAYG LSEQAGVTPE AWAQLSPALL QQQLSGACTS QSRPPVQDQL SQSERY (23-327 aa encoded by BC062625)

Target Information

The zinc transporter ZIP4, also known as SLC39A4, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP4 was initially identified as zinc-uptake transporter in the intestine and as a candidate gene for acrodermatitis enteropathica (AE), a rare inherited defect in the absorption of dietary zinc. Similar to other ZIP family members, aberrant expression of ZIP4 has been linked to cancer, specifically the progression and aggressiveness of pancreatic cancer. ZIP4 expression has also been shown to be activated in hepatocellular carcinomas, acting to repress apoptosis, enhance cell cycle and increase migration, suggesting ZIP4 may play a role in multiple types of cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-β Signaling Axis in Pancreatic Cancer.

Gastroenterology

Shi X,Yang J,Liu M,Zhang Y,Zhou Z,Luo W,Fung KM,Xu C,Bronze MS,Houchen CW,Li M

Wed Jun 01 00:00:00 UTC 2022

Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-β Signaling Axis in Pancreatic Cancer.

Gastroenterology

Shi X,Yang J,Liu M,Zhang Y,Zhou Z,Luo W,Fung KM,Xu C,Bronze MS,Houchen CW,Li M

Wed Jun 01 00:00:00 UTC 2022

Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-β Signaling Axis in Pancreatic Cancer.

Gastroenterology

Shi X,Yang J,Liu M,Zhang Y,Zhou Z,Luo W,Fung KM,Xu C,Bronze MS,Houchen CW,Li M

Wed Jun 01 00:00:00 UTC 2022

Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-β Signaling Axis in Pancreatic Cancer.

Gastroenterology

Shi X,Yang J,Liu M,Zhang Y,Zhou Z,Luo W,Fung KM,Xu C,Bronze MS,Houchen CW,Li M

Wed Jun 01 00:00:00 UTC 2022

RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.

Molecular oncology

Scheiter A,Evert K,Reibenspies L,Cigliano A,Annweiler K,Müller K,Pöhmerer LM,Xu H,Cui G,Itzel T,Materna-Reichelt S,Coluccio A,Honarnejad K,Teufel A,Brochhausen C,Dombrowski F,Chen X,Evert M,Calvisi DF,Utpatel K

Tue Mar 01 00:00:00 UTC 2022

RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.

Molecular oncology

Tue Mar 01 00:00:00 UTC 2022

RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.

Molecular oncology

Tue Mar 01 00:00:00 UTC 2022

RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.

Molecular oncology

Tue Mar 01 00:00:00 UTC 2022

Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer.

Gastroenterology

Zhou Z,Ren Y,Yang J,Liu M,Shi X,Luo W,Fung KM,Xu C,Bronze MS,Zhang Y,Houchen CW,Li M

Tue Nov 01 00:00:00 UTC 2022

Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors.

Virchows Archiv : an international journal of pathology

Miyai K,Yonekura Y,Ito K,Matsukuma S,Tsuda H

Wed Dec 01 00:00:00 UTC 2021

Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity.

International journal of molecular sciences

Vogel-González M,Musa-Afaneh D,Rivera Gil P,Vicente R

Wed Aug 25 00:00:00 UTC 2021

Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity.

International journal of molecular sciences

Vogel-González M,Musa-Afaneh D,Rivera Gil P,Vicente R

Wed Aug 25 00:00:00 UTC 2021

A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer.

Cancers

Fan Q,Li L,Wang TL,Emerson RE,Xu Y

Thu Jul 29 00:00:00 UTC 2021

A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer.

Cancers

Fan Q,Li L,Wang TL,Emerson RE,Xu Y

Thu Jul 29 00:00:00 UTC 2021

ZIP4 promotes non-small cell lung cancer metastasis by activating snail-N-cadherin signaling axis.

Cancer letters

Jiang Y,Zhan H,Zhang Y,Yang J,Liu M,Xu C,Fan X,Zhang J,Zhou Z,Shi X,Ramesh R,Li M

Tue Aug 24 00:00:00 UTC 2021

ZIP4 promotes non-small cell lung cancer metastasis by activating snail-N-cadherin signaling axis.

Cancer letters

Jiang Y,Zhan H,Zhang Y,Yang J,Liu M,Xu C,Fan X,Zhang J,Zhou Z,Shi X,Ramesh R,Li M

Tue Aug 24 00:00:00 UTC 2021

ZIP4 promotes non-small cell lung cancer metastasis by activating snail-N-cadherin signaling axis.

Cancer letters

Jiang Y,Zhan H,Zhang Y,Yang J,Liu M,Xu C,Fan X,Zhang J,Zhou Z,Shi X,Ramesh R,Li M

Tue Aug 24 00:00:00 UTC 2021

ZIP4 promotes non-small cell lung cancer metastasis by activating snail-N-cadherin signaling axis.

Cancer letters

Jiang Y,Zhan H,Zhang Y,Yang J,Liu M,Xu C,Fan X,Zhang J,Zhou Z,Shi X,Ramesh R,Li M

Tue Aug 24 00:00:00 UTC 2021

ZIP4 Is a Novel Cancer Stem Cell Marker in High-Grade Serous Ovarian Cancer.

Cancers

Fan Q,Zhang W,Emerson RE,Xu Y

Wed Dec 09 00:00:00 UTC 2020

ZIP4 Is a Novel Cancer Stem Cell Marker in High-Grade Serous Ovarian Cancer.

Cancers

Fan Q,Zhang W,Emerson RE,Xu Y

Wed Dec 09 00:00:00 UTC 2020

ZIP4 Is a Novel Cancer Stem Cell Marker in High-Grade Serous Ovarian Cancer.

Cancers

Fan Q,Zhang W,Emerson RE,Xu Y

Wed Dec 09 00:00:00 UTC 2020

ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells.

Gastroenterology

Liu M,Zhang Y,Yang J,Cui X,Zhou Z,Zhan H,Ding K,Tian X,Yang Z,Fung KA,Edil BH,Postier RG,Bronze MS,Fernandez-Zapico ME,Stemmler MP,Brabletz T,Li YP,Houchen CW,Li M

Sat Feb 01 00:00:00 UTC 2020

SLC39A4 as a Novel Prognosis Marker Promotes Tumor Progression in Esophageal Squamous Cell Carcinoma.

OncoTargets and therapy

Xia C,Chen X,Li J,Chen P

Thu Apr 14 00:00:00 UTC 2022

SLC39A4 as a Novel Prognosis Marker Promotes Tumor Progression in Esophageal Squamous Cell Carcinoma.

OncoTargets and therapy

Xia C,Chen X,Li J,Chen P

Thu Apr 14 00:00:00 UTC 2022

Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells.

Cell death & disease

Zeng Q,Liu YM,Liu J,Han J,Guo JX,Lu S,Huang XM,Yi P,Lang JY,Zhang P,Wang CT

Mon Aug 05 00:00:00 UTC 2019

Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells.

Cell death & disease

Zeng Q,Liu YM,Liu J,Han J,Guo JX,Lu S,Huang XM,Yi P,Lang JY,Zhang P,Wang CT

Mon Aug 05 00:00:00 UTC 2019

Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells.

Cell death & disease

Zeng Q,Liu YM,Liu J,Han J,Guo JX,Lu S,Huang XM,Yi P,Lang JY,Zhang P,Wang CT

Mon Aug 05 00:00:00 UTC 2019

A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.

Scientific reports

Ohta S,Ikemoto T,Wada Y,Saito Y,Yamada S,Imura S,Morine Y,Shimada M

Tue Dec 10 00:00:00 UTC 2019

ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.