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Invitrogen
ZIPK Monoclonal Antibody (4H4C8)
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Product Details
MA5-31710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4H4C8
Immunogen
Purified recombinant fragment of human DAPK3 (AA: 28-161) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2787334
Product Specific Information
MA5-31710 has been tested in indirect ELISA.
Target Information
DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP kinase 3; DAP-like kinase; DAP3K; Death-associated protein kinase 3; Dlk; MYPT1 kinase; ZIP kinase isoform; ZIP-kinase; Zipper-interacting protein kinase
Gene Aliases: DAPK3; DLK; ZIP; ZIPK
UniProt ID: (Human) O43293
Entrez Gene ID: (Human) 1613
cytokinesis
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
regulation of smooth muscle contraction
regulation of mitotic nuclear division
regulation of mitotic cell cycle
regulation of cell shape
regulation of autophagy
covalent chromatin modification
negative regulation of translation
neuron differentiation
positive regulation of cell migration
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
regulation of myosin II filament organization
protein autophosphorylation
regulation of focal adhesion assembly
cellular response to interferon-gamma
positive regulation of canonical Wnt signaling pathway
apoptotic signaling pathway
regulation of cell motility
regulation of actin cytoskeleton reorganization
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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