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Proteintech
ZMYND10 Polyclonal Antibody
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Product Details
14431-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZMYND10 Fusion Protein Ag5808 (1-440 aa encoded by BC033732)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGDLELLLP GEAEVLVRGL RSFPLREMGS EGWNQQHENL EKLNMQAILD ATVSQGEPIQ ELLVTHGKVP TLVEELIAVE MWKQKVFPVF CRVEDFKPQN TFPIYMVVHH EASIINLLET VFFHKEVCES AEDTVLDLVD YCHRKLTLLV AQSGCGGPPE GEGSQDSNPM QELQKQAELM EFEIALKALS VLRYITDCVD SLSLSTLSRM LSTHNLPCLL VELLEHSPWS RREGGKLQQF EGSRWHTVAP SEQQKLSKLD GQVWIALYNL LLSPEAQARY CLTSFAKGRL LKLRAFLTDT LLDQLPNLAH LQSFLAHLTL TETQPPKKDL VLEQIPEIWE RLERENRGKW QAIAKHQLQH VFSPSEQDLR LQARRWAETY RLDVLEAVAP ERPRCAYCSA EASKRCSRCQ NEWYCCRECQ VKHWEKHGKT CVLAAQGDRA K (1-440 aa encoded by BC033732)
Target Information
The ZMYND10 gene encodes a protein that contains a MYND-type zinc finger domain, playing a crucial role in the assembly and function of cilia. Specifically, ZMYND10 is essential for the proper axonemal assembly of both inner and outer dynein arms, which are critical components of motile cilia. Mutations in ZMYND10 are associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by defective ciliary motility leading to recurrent respiratory infections and male infertility. In model organisms like mice and Drosophila, ZMYND10 expression is restricted to tissues and cells with motile cilia, such as chordotonal sensory neurons and sperm cells. Additionally, ZMYND10 has been identified as an epigenetically regulated tumor suppressor in various cancers, with its downregulation affecting processes like cell proliferation and tumor progression. The gene's dual role in ciliary function and tumorigenesis underlines its importance in both normal cellular physiology and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein BLu; Zinc finger MYND domain-containing protein 10; zinc finger, MYND domain-containing 10; zinc finger, MYND-type containing 10
Gene Aliases: BLU; CILD22; FLU; LUCA12.4; ZMYND10
UniProt ID: (Human) O75800, (Mouse) Q99ML0, (Rat) Q6AXZ5
Entrez Gene ID: (Human) 51364, (Mouse) 114602, (Rat) 363139
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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