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Abnova
ZMYND10 Polyclonal Antibody, MaxPab™
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Product Details
H00051364-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZMYND10 (NP_056980.2, 1 a.a. approximately 440 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME FEIALKALSV LRYITDCVDS LSLSTLSRML STHNLPCLLV ELLEHSPWSR REGGKLQQFE GSRWHTVAPS EQQKLSKLDG QVWIALYNLL LSPEAQARYC LTSFAKGRLL KLRAFLTDTL LDQLPNLAHL QSFLAHLTLT ETQPPKKDLV LEQIPEIWER LERENRGKWQ AIAKHQLQHV FSPSEQDLRL QARRWAETYR LDVLEAVAPE RPRCAYCSAE ASKRCSRCQN EWYCCRECQV KHWEKHGKTC VLAAQGDRAK
Target Information
The ZMYND10 gene encodes a protein that contains a MYND-type zinc finger domain, playing a crucial role in the assembly and function of cilia. Specifically, ZMYND10 is essential for the proper axonemal assembly of both inner and outer dynein arms, which are critical components of motile cilia. Mutations in ZMYND10 are associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by defective ciliary motility leading to recurrent respiratory infections and male infertility. In model organisms like mice and Drosophila, ZMYND10 expression is restricted to tissues and cells with motile cilia, such as chordotonal sensory neurons and sperm cells. Additionally, ZMYND10 has been identified as an epigenetically regulated tumor suppressor in various cancers, with its downregulation affecting processes like cell proliferation and tumor progression. The gene's dual role in ciliary function and tumorigenesis underlines its importance in both normal cellular physiology and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein BLu; Zinc finger MYND domain-containing protein 10; zinc finger, MYND-type containing 10
Gene Aliases: BLU; CILD22; FLU; LUCA12.4; ZMYND10
UniProt ID: (Human) O75800
Entrez Gene ID: (Human) 51364
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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