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Invitrogen
ZMYND8 Polyclonal Antibody
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ZMYND8 Antibody (PA5-104507) in IHC (P)
Immunohistochemistry analysis of ZMYND8 in human ovarian cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ZMYND8 polyclonal antibody (Product # PA5-104507) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104507
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZMYND8(Accession Q9ULU4), corresponding to amino acid residues D599-Q624.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853808
Product Specific Information
Antibody detects endogenous levels of total PKCB1.
Target Information
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTCL tumor antigen se14-3; CTCL-associated antigen se14-3; Cutaneous T-cell lymphoma-associated antigen se14-3; MYND-type zinc finger-containing chromatin reader ZMYND8; predicted protein of HQ2893; protein kinase C binding protein 1; Protein kinase C-binding protein 1; Rack7; Transcription coregulator ZMYND8; Zinc finger MYND domain-containing protein 8; zinc finger, MYND-type containing 8
Gene Aliases: 1110013E22Rik; 2010005I16Rik; 3632413B07Rik; AI316811; AL024039; KIAA1125; PRKCBP1; PRO2893; RACK7; ZMYND8
UniProt ID: (Human) Q9ULU4
Entrez Gene ID: (Human) 23613, (Mouse) 228880
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription corepressor activity
chromatin binding
transcription cofactor activity
protein binding
zinc ion binding
histone binding
protein N-terminus binding
repressing transcription factor binding
molecular_function
biological_process
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
positive regulation of filopodium assembly
positive regulation of dendritic spine development
modulation of excitatory postsynaptic potential
regulation of postsynaptic density protein 95 clustering
positive regulation of dendritic spine maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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