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Proteintech
ZNF451 Polyclonal Antibody
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Product Details
25228-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZNF451 Fusion Protein Ag18346 (1-350 aa encoded by BC021712)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGDPGSEII ESVPPAGPEA SESTTDENED DIQFVSEGPL RPVLEYIDLV SSDDEEPSTS YTDENIKRKD HIDYQKDKVA LTLARLARHV EVEKQQKEEK NRAFREKIDF QHAHGLQELE FIRGHSDTEA ARLCVDQWLK MPGLKTGTIN CGTKSSFRRG GHTWVSGKPI LCPIMHCNKE FDNGHLLLGH LKRFDHSPCD PTITLHGPFF SSFACVVCYK KFVTQQQYRD HLFDKEATDD GHNNNLLPQI IQCFACPNCF LLFSRKEECS KHMSGKNHFH QSFKLGDNKG IAHPISFPSF AKKLLISLCK DVPFQVKCVA CHKTLRSHME LTAHFRVHCR NAGPVAVAEK S (1-350 aa encoded by BC021712)
Target Information
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coactivator for steroid receptors; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein transferase ZNF451; Zinc finger protein 451
Gene Aliases: COASTER; dJ417I1.1; KIAA0576; KIAA1702; ZNF451
UniProt ID: (Human) Q9Y4E5
Entrez Gene ID: (Human) 26036
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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