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Product Details
20900-1-AP
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZNF496 Fusion Protein Ag15015 (238-587 aa encoded by BC007263)
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LDPAQTGFY GEFIIGEDYG VSMPPNDLAA QPDLSQGEEN EPRVPELQDL QGKEVPQVSY LDSPSLQPFQ VEERRKREEL QVPEFQACPQ TVVPQNTYPA GGNPRSLENS LDEEVTIEIV LSSSGDEDSQ HGPYCTEELG SPTEKQRSLP ASHRSSTEAG GEVQTSKKSY VCPNCGKIFR WRVNFIRHLR SRREQEKPHE CSVCGELFSD SEDLDGHLES HEAQKPYRCG ACGKSFRLNS HLLSHRRIHL QPDRLQPVEK REQAASEDAD KGPKEPLENG KAKLSFQCCE CGKAFQRHDH LARHRSHFHL KDKARPFQCR YCVKSFTQNY DLLRHERLHM KRRSKQALNS Y (238-587 aa encoded by BC007263)
Target Information
ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC15548; NSD1 (nuclear receptor binding SET-domain containing 1)-interacting zinc finger protein 1; NSD1-interacting zinc finger protein 1; Zinc finger protein 496; Zinc finger protein with KRAB and SCAN domains 17
Gene Aliases: NIZP1; Nizp11; ZFP496; ZKSCAN17; ZNF496; ZSCAN49
UniProt ID: (Human) Q96IT1, (Mouse) Q5SXI5
Entrez Gene ID: (Human) 84838, (Mouse) 268417
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