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Invitrogen
ZNF521 Polyclonal Antibody
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Product Details
PA5-54680
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZNF521. Recombinant protein control fragment (Product #RP-93655).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2650171
Product Specific Information
Immunogen sequence: KQDLVKLDIN GLPYGLCAGC VNLSKSASPG INVPPGTNRP GLGQNENLSA IEGKGKVGGL KTRCSSCNVK FESE
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 85%.
Target Information
The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Early hematopoietic zinc finger protein; LYST-interacting protein 3; Zinc finger protein 521
Gene Aliases: EHZF; Evi3; LIP3; ZNF521
UniProt ID: (Human) Q96K83
Entrez Gene ID: (Human) 25925
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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